| http://purl.uniprot.org/citations/33110146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33110146 | http://www.w3.org/2000/01/rdf-schema#comment | "The Akt family is comprised of three unique homologous proteins with isoform-specific effects, but isoform-specific in vivo data are limited in follicular thyroid cancer (FTC), a PI3 kinase-driven tumor. Prior studies demonstrated that PI3K/Akt signaling is important in thyroid hormone receptor βPV/PV knock-in (PV) mice that develop metastatic thyroid cancer that most closely resembles FTC. To determine the roles of Akt isoforms in this model we crossed Akt1-/-, Akt2-/-, and Akt3-/- mice with PV mice. Over 12 months, thyroid size was reduced for the Akt null crosses (p < 0.001). Thyroid cancer development and local invasion were delayed in only the PVPV-Akt1 knock out (KO) mice in association with increased apoptosis with no change in proliferation. Primary-cultured PVPV-Akt1KO thyrocytes uniquely displayed a reduced cell motility. In contrast, loss of any Akt isoform reduced lung metastasis while vascular invasion was reduced with Akt1 or 3 loss. Microarray of thyroid RNA displayed incomplete overlap between the Akt KO models. The most upregulated gene was the dendritic cell (DC) marker CD209a only in PVPV-Akt1KO thyroids. Immunohistochemistry demonstrated an increase in CD209a-expressing cells in the PVPV-Akt1KO thyroids. In summary, Akt isoforms exhibit common and differential functions that regulate local and metastatic progression in this model of thyroid cancer."xsd:string |
| http://purl.uniprot.org/citations/33110146 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-020-75529-0"xsd:string |
| http://purl.uniprot.org/citations/33110146 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/33110146 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/33110146 | http://purl.uniprot.org/core/author | "Tsichlis P.N."xsd:string |
| http://purl.uniprot.org/citations/33110146 | http://purl.uniprot.org/core/author | "Saji M."xsd:string |
| http://purl.uniprot.org/citations/33110146 | http://purl.uniprot.org/core/author | "Kim C.S."xsd:string |
| http://purl.uniprot.org/citations/33110146 | http://purl.uniprot.org/core/author | "Cheng S.Y."xsd:string |
| http://purl.uniprot.org/citations/33110146 | http://purl.uniprot.org/core/author | "La Perle K."xsd:string |
| http://purl.uniprot.org/citations/33110146 | http://purl.uniprot.org/core/author | "Ringel M.D."xsd:string |
| http://purl.uniprot.org/citations/33110146 | http://purl.uniprot.org/core/author | "Coombes K."xsd:string |
| http://purl.uniprot.org/citations/33110146 | http://purl.uniprot.org/core/author | "Khanal T."xsd:string |
| http://purl.uniprot.org/citations/33110146 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33110146 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/33110146 | http://purl.uniprot.org/core/pages | "18316"xsd:string |
| http://purl.uniprot.org/citations/33110146 | http://purl.uniprot.org/core/title | "Akt isoform-specific effects on thyroid cancer development and progression in a murine thyroid cancer model."xsd:string |
| http://purl.uniprot.org/citations/33110146 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/33110146 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33110146 |
| http://purl.uniprot.org/citations/33110146 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33110146 |
| http://purl.uniprot.org/uniprot/#_A0A286YD21-mappedCitation-33110146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33110146 |
| http://purl.uniprot.org/uniprot/#_A0A286YDB1-mappedCitation-33110146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33110146 |
| http://purl.uniprot.org/uniprot/#_D3Z0M3-mappedCitation-33110146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33110146 |
| http://purl.uniprot.org/uniprot/#_D3Z5X2-mappedCitation-33110146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33110146 |
| http://purl.uniprot.org/uniprot/#_D3YXM7-mappedCitation-33110146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33110146 |