Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/33115371http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/33115371http://www.w3.org/2000/01/rdf-schema#comment"

Background

Milk fat globule epidermal growth factor (MFG-E8) is related secreted protein which links phosphatidylserine on apoptotic cells and integrin αvβ3/5 on phagocytes. To clarify the clinical significance of MFG-E8 in SLE, we analyzed the correlation between expression level of MFG-E8 in circulating phagocytic leukocytes and clinical parameters of patients.

Methods

The study was conducted under a multi-center, prospective cohort design. Patients with one or both BILAG A or B, or SLEDAI-2 K ≥ 4 with clinical symptoms were defined as the active SLE group. Expression of MFG-E8 on monocytes and concentration in serum were measured by FACS and ELISA, respectively.

Results

96 subjects were enrolled. The absolute number and proportion of MFG-E8-positive monocytes to total monocytes were significantly higher in the active SLE group (p < 0.01). Importantly, the proportion was also significantly correlated with SLEDAI-2K, clinical SLEDAI, as well as serum levels of anti-ds-DNA antibody and complement and C1q. In addition, the proportion of MFG-E8-positive monocytes to total monocytes was significantly decreased from baseline in active SLE patients after 6 months' treatment and increased concordantly with disease activity in 6 refractory cases. Further, in receiver operating characteristic curve analysis for discrimination between active and inactive SLE, the AUC of the proportion of MFG-E8 was 0.854, which was equivalent to classical activity markers such as anti-ds DNA antibody (0.776), complement (0.897) and C1q (0.815).

Conclusions

The proportion of MFG-E8-positive monocytes to total monocytes in peripheral blood was positively associated with disease activity in SLE and may be a novel biomarker of disease activity."xsd:string
http://purl.uniprot.org/citations/33115371http://purl.org/dc/terms/identifier"doi:10.1177/0961203320967761"xsd:string
http://purl.uniprot.org/citations/33115371http://purl.uniprot.org/core/author"Kikuchi J."xsd:string
http://purl.uniprot.org/citations/33115371http://purl.uniprot.org/core/author"Suzuki K."xsd:string
http://purl.uniprot.org/citations/33115371http://purl.uniprot.org/core/author"Seki N."xsd:string
http://purl.uniprot.org/citations/33115371http://purl.uniprot.org/core/author"Saito S."xsd:string
http://purl.uniprot.org/citations/33115371http://purl.uniprot.org/core/author"Yoshimoto K."xsd:string
http://purl.uniprot.org/citations/33115371http://purl.uniprot.org/core/author"Takeuchi T."xsd:string
http://purl.uniprot.org/citations/33115371http://purl.uniprot.org/core/author"Takeshita M."xsd:string
http://purl.uniprot.org/citations/33115371http://purl.uniprot.org/core/author"Oshima H."xsd:string
http://purl.uniprot.org/citations/33115371http://purl.uniprot.org/core/author"Yamaoka K."xsd:string
http://purl.uniprot.org/citations/33115371http://purl.uniprot.org/core/author"Yasuoka H."xsd:string
http://purl.uniprot.org/citations/33115371http://purl.uniprot.org/core/author"Ushikubo M."xsd:string
http://purl.uniprot.org/citations/33115371http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/33115371http://purl.uniprot.org/core/name"Lupus"xsd:string
http://purl.uniprot.org/citations/33115371http://purl.uniprot.org/core/pages"61-69"xsd:string
http://purl.uniprot.org/citations/33115371http://purl.uniprot.org/core/title"Milk fat globule epidermal growth factor 8 (MFG-E8) on monocytes is a novel biomarker of disease activity in systemic lupus erythematosus."xsd:string
http://purl.uniprot.org/citations/33115371http://purl.uniprot.org/core/volume"30"xsd:string
http://purl.uniprot.org/citations/33115371http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/33115371
http://purl.uniprot.org/citations/33115371http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/33115371
http://purl.uniprot.org/uniprot/#_A0A8Q3SIZ9-mappedCitation-33115371http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/33115371
http://purl.uniprot.org/uniprot/#_B4E396-mappedCitation-33115371http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/33115371
http://purl.uniprot.org/uniprot/#_B3KTQ2-mappedCitation-33115371http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/33115371
http://purl.uniprot.org/uniprot/#_H0YKB5-mappedCitation-33115371http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/33115371
▶