| http://purl.uniprot.org/citations/33121533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33121533 | http://www.w3.org/2000/01/rdf-schema#comment | "Understanding the biology underlying the mechanisms and pathways regulating pancreatic β cell development is necessary to understand the pathology of diabetes mellitus (DM), which is characterized by the progressive reduction in insulin-producing β cell mass. Pluripotent stem cells (PSCs) can potentially offer an unlimited supply of functional β cells for cellular therapy and disease modeling of DM. Homeobox protein NKX6.1 is a transcription factor (TF) that plays a critical role in pancreatic β cell function and proliferation. In human pancreatic islet, NKX6.1 expression is exclusive to β cells and is undetectable in other islet cells. Several reports showed that activation of NKX6.1 in PSC-derived pancreatic progenitors (MPCs), expressing PDX1 (PDX1+/NKX6.1+), warrants their future commitment to monohormonal β cells. However, further differentiation of MPCs lacking NKX6.1 expression (PDX1+/NKX6.1-) results in an undesirable generation of non-functional polyhormonal β cells. The importance of NKX6.1 as a crucial regulator in MPC specification into functional β cells directs attentions to further investigating its mechanism and enhancing NKX6.1 expression as a means to increase β cell function and mass. Here, we shed light on the role of NKX6.1 during pancreatic β cell development and in directing the MPCs to functional monohormonal lineage. Furthermore, we address the transcriptional mechanisms and targets of NKX6.1 as well as its association with diabetes."xsd:string |
| http://purl.uniprot.org/citations/33121533 | http://purl.org/dc/terms/identifier | "doi:10.1186/s13287-020-01977-0"xsd:string |
| http://purl.uniprot.org/citations/33121533 | http://purl.uniprot.org/core/author | "Abdelalim E.M."xsd:string |
| http://purl.uniprot.org/citations/33121533 | http://purl.uniprot.org/core/author | "Aigha I.I."xsd:string |
| http://purl.uniprot.org/citations/33121533 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33121533 | http://purl.uniprot.org/core/name | "Stem Cell Res Ther"xsd:string |
| http://purl.uniprot.org/citations/33121533 | http://purl.uniprot.org/core/pages | "459"xsd:string |
| http://purl.uniprot.org/citations/33121533 | http://purl.uniprot.org/core/title | "NKX6.1 transcription factor: a crucial regulator of pancreatic beta cell development, identity, and proliferation."xsd:string |
| http://purl.uniprot.org/citations/33121533 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/33121533 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33121533 |
| http://purl.uniprot.org/citations/33121533 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33121533 |
| http://purl.uniprot.org/uniprot/#_P78426-mappedCitation-33121533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33121533 |
| http://purl.uniprot.org/uniprot/P78426 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33121533 |