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| http://purl.uniprot.org/citations/33125872 | http://www.w3.org/2000/01/rdf-schema#comment | "Precise patterns of synaptic connections between neurons are encoded in their genetic programs. Here, we use single-cell RNA sequencing to profile neuronal transcriptomes at multiple stages in the developing Drosophila visual system. We devise an efficient strategy for profiling neurons at multiple time points in a single pool, thereby minimizing batch effects and maximizing the reliability of time-course data. A transcriptional atlas spanning multiple stages is generated, including more than 150 distinct neuronal populations; of these, 88 are followed through synaptogenesis. This analysis reveals a common (pan-neuronal) program unfolding in highly coordinated fashion in all neurons, including genes encoding proteins comprising the core synaptic machinery and membrane excitability. This program is overlaid by cell-type-specific programs with diverse cell recognition molecules expressed in different combinations and at different times. We propose that a pan-neuronal program endows neurons with the competence to form synapses and that cell-type-specific programs control synaptic specificity."xsd:string |
| http://purl.uniprot.org/citations/33125872 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2020.10.006"xsd:string |
| http://purl.uniprot.org/citations/33125872 | http://purl.uniprot.org/core/author | "Yoo J."xsd:string |
| http://purl.uniprot.org/citations/33125872 | http://purl.uniprot.org/core/author | "Zipursky S.L."xsd:string |
| http://purl.uniprot.org/citations/33125872 | http://purl.uniprot.org/core/author | "Sanfilippo P."xsd:string |
| http://purl.uniprot.org/citations/33125872 | http://purl.uniprot.org/core/author | "Kurmangaliyev Y.Z."xsd:string |
| http://purl.uniprot.org/citations/33125872 | http://purl.uniprot.org/core/author | "Valdes-Aleman J."xsd:string |
| http://purl.uniprot.org/citations/33125872 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33125872 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/33125872 | http://purl.uniprot.org/core/pages | "1045-1057.e6"xsd:string |
| http://purl.uniprot.org/citations/33125872 | http://purl.uniprot.org/core/title | "Transcriptional Programs of Circuit Assembly in the Drosophila Visual System."xsd:string |
| http://purl.uniprot.org/citations/33125872 | http://purl.uniprot.org/core/volume | "108"xsd:string |
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