| http://purl.uniprot.org/citations/33147456 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33147456 | http://www.w3.org/2000/01/rdf-schema#comment | "Systemic lupus erythematosus (SLE) is a severe autoimmune disease mediated by pathogenic autoantibodies. While complement protein C4 is associated with SLE, its isoforms (C4A and C4B) are not equal in their impact. Despite being 99% homologous, genetic studies identified C4A as more protective than C4B. By generating gene-edited mouse strains expressing either human C4A or C4B and crossing these with the 564lgi lupus strain, we show that, overall, C4A-like 564Igi mice develop less humoral autoimmunity than C4B-like 564Igi mice. This includes a decrease in the number of GCs, autoreactive B cells, autoantibodies, and memory B cells. The higher efficiency of C4A in inducing self-antigen clearance is associated with the follicular exclusion of autoreactive B cells. These results explain how the C4A isoform is protective in lupus and suggest C4A as a possible replacement therapy in lupus."xsd:string |
| http://purl.uniprot.org/citations/33147456 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.108330"xsd:string |
| http://purl.uniprot.org/citations/33147456 | http://purl.uniprot.org/core/author | "Simoni L."xsd:string |
| http://purl.uniprot.org/citations/33147456 | http://purl.uniprot.org/core/author | "Utz P.J."xsd:string |
| http://purl.uniprot.org/citations/33147456 | http://purl.uniprot.org/core/author | "Carroll M.C."xsd:string |
| http://purl.uniprot.org/citations/33147456 | http://purl.uniprot.org/core/author | "Presumey J."xsd:string |
| http://purl.uniprot.org/citations/33147456 | http://purl.uniprot.org/core/author | "van der Poel C.E."xsd:string |
| http://purl.uniprot.org/citations/33147456 | http://purl.uniprot.org/core/author | "Chang S.E."xsd:string |
| http://purl.uniprot.org/citations/33147456 | http://purl.uniprot.org/core/author | "Castrillon C."xsd:string |
| http://purl.uniprot.org/citations/33147456 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33147456 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/33147456 | http://purl.uniprot.org/core/pages | "108330"xsd:string |
| http://purl.uniprot.org/citations/33147456 | http://purl.uniprot.org/core/title | "Complement C4A Regulates Autoreactive B Cells in Murine Lupus."xsd:string |
| http://purl.uniprot.org/citations/33147456 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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| http://purl.uniprot.org/citations/33147456 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33147456 |
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