| http://purl.uniprot.org/citations/33147467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33147467 | http://www.w3.org/2000/01/rdf-schema#comment | "The germinal center (GC) reaction is essential for long-lived humoral immunity. However, molecular requirements for the induction of Bcl6, the master regulator for GC B cell differentiation, remain unclear. Through screening for cytokines and other stimuli that regulate Bcl6 expression, we identify IL-4 as the strongest inducer. IL-4 signaling alters the metabolomic profile in activated B cells and induces accumulation of the TCA cycle intermediate α-ketoglutarate (αKG), which is required for activation of the Bcl6 gene locus. Mechanistically, after IL-4 treatment, STAT6 bound to the known enhancers in the Bcl6 locus recruits UTX, a demethylase for the repressive histone mark H3K27me3 that requires αKG as a cofactor. In turn, the H3K27me3 demethylation activates the enhancers and transcription of the Bcl6 gene. We propose that IL-4-mediated metabolic reprogramming in B cells is pivotal for epigenomic activation of Bcl6 expression to promote GC B cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/33147467 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2020.108333"xsd:string |
| http://purl.uniprot.org/citations/33147467 | http://purl.uniprot.org/core/author | "Kitamura D."xsd:string |
| http://purl.uniprot.org/citations/33147467 | http://purl.uniprot.org/core/author | "Fukao S."xsd:string |
| http://purl.uniprot.org/citations/33147467 | http://purl.uniprot.org/core/author | "Haniuda K."xsd:string |
| http://purl.uniprot.org/citations/33147467 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33147467 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/33147467 | http://purl.uniprot.org/core/pages | "108333"xsd:string |
| http://purl.uniprot.org/citations/33147467 | http://purl.uniprot.org/core/title | "Metabolic Reprogramming Induces Germinal Center B Cell Differentiation through Bcl6 Locus Remodeling."xsd:string |
| http://purl.uniprot.org/citations/33147467 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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