| http://purl.uniprot.org/citations/33157039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33157039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33157039 | http://www.w3.org/2000/01/rdf-schema#comment | "Retrons are bacterial genetic elements comprised of a reverse transcriptase (RT) and a non-coding RNA (ncRNA). The RT uses the ncRNA as template, generating a chimeric RNA/DNA molecule in which the RNA and DNA components are covalently linked. Although retrons were discovered three decades ago, their function remained unknown. We report that retrons function as anti-phage defense systems. The defensive unit is composed of three components: the RT, the ncRNA, and an effector protein. We examined multiple retron systems and show that they confer defense against a broad range of phages via abortive infection. Focusing on retron Ec48, we show evidence that it "guards" RecBCD, a complex with central anti-phage functions in bacteria. Inhibition of RecBCD by phage proteins activates the retron, leading to abortive infection and cell death. Thus, the Ec48 retron forms a second line of defense that is triggered if the first lines of defense have collapsed."xsd:string |
| http://purl.uniprot.org/citations/33157039 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2020.09.065"xsd:string |
| http://purl.uniprot.org/citations/33157039 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2020.09.065"xsd:string |
| http://purl.uniprot.org/citations/33157039 | http://purl.uniprot.org/core/author | "Bernheim A."xsd:string |
| http://purl.uniprot.org/citations/33157039 | http://purl.uniprot.org/core/author | "Bernheim A."xsd:string |
| http://purl.uniprot.org/citations/33157039 | http://purl.uniprot.org/core/author | "Fedorenko T."xsd:string |
| http://purl.uniprot.org/citations/33157039 | http://purl.uniprot.org/core/author | "Fedorenko T."xsd:string |
| http://purl.uniprot.org/citations/33157039 | http://purl.uniprot.org/core/author | "Millman A."xsd:string |
| http://purl.uniprot.org/citations/33157039 | http://purl.uniprot.org/core/author | "Millman A."xsd:string |
| http://purl.uniprot.org/citations/33157039 | http://purl.uniprot.org/core/author | "Oppenheimer-Shaanan Y."xsd:string |
| http://purl.uniprot.org/citations/33157039 | http://purl.uniprot.org/core/author | "Oppenheimer-Shaanan Y."xsd:string |
| http://purl.uniprot.org/citations/33157039 | http://purl.uniprot.org/core/author | "Leavitt A."xsd:string |
| http://purl.uniprot.org/citations/33157039 | http://purl.uniprot.org/core/author | "Leavitt A."xsd:string |
| http://purl.uniprot.org/citations/33157039 | http://purl.uniprot.org/core/author | "Sorek R."xsd:string |
| http://purl.uniprot.org/citations/33157039 | http://purl.uniprot.org/core/author | "Sorek R."xsd:string |
| http://purl.uniprot.org/citations/33157039 | http://purl.uniprot.org/core/author | "Stokar-Avihail A."xsd:string |
| http://purl.uniprot.org/citations/33157039 | http://purl.uniprot.org/core/author | "Stokar-Avihail A."xsd:string |
| http://purl.uniprot.org/citations/33157039 | http://purl.uniprot.org/core/author | "Voichek M."xsd:string |
| http://purl.uniprot.org/citations/33157039 | http://purl.uniprot.org/core/author | "Voichek M."xsd:string |
| http://purl.uniprot.org/citations/33157039 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33157039 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33157039 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/33157039 | http://purl.uniprot.org/core/name | "Cell"xsd:string |