| http://purl.uniprot.org/citations/33159168 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33159168 | http://www.w3.org/2000/01/rdf-schema#comment | "The immune microenvironment of tumors can play a critical role in promoting or inhibiting tumor progression depending on the context. We present evidence that tumor-associated macrophages/microglia (TAMs) can promote tumor progression in the sonic hedgehog subgroup of medulloblastoma (SHH-MB). By combining longitudinal manganese-enhanced magnetic resonance imaging (MEMRI) and immune profiling of a sporadic mouse model of SHH-MB, we found the density of TAMs is higher in the ~50% of tumors that progress to lethal disease. Furthermore, reducing regulatory T cells or eliminating B and T cells in Rag1 mutants does not alter SHH-MB tumor progression. As TAMs are a dominant immune component in tumors and are normally dependent on colony-stimulating factor 1 receptor (CSF1R), we treated mice with a CSF1R inhibitor, PLX5622. Significantly, PLX5622 reduces a subset of TAMs, prolongs mouse survival, and reduces the volume of most tumors within 4 weeks of treatment. Moreover, concomitant with a reduction in TAMs the percentage of infiltrating cytotoxic T cells is increased, indicating a change in the tumor environment. Our studies in an immunocompetent preclinical mouse model demonstrate TAMs can have a functional role in promoting SHH-MB progression. Thus, CSF1R inhibition could have therapeutic potential for a subset of SHH-MB patients."xsd:string |
| http://purl.uniprot.org/citations/33159168 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41388-020-01536-0"xsd:string |
| http://purl.uniprot.org/citations/33159168 | http://purl.uniprot.org/core/author | "Korshunov A."xsd:string |
| http://purl.uniprot.org/citations/33159168 | http://purl.uniprot.org/core/author | "Joyner A.L."xsd:string |
| http://purl.uniprot.org/citations/33159168 | http://purl.uniprot.org/core/author | "Lao Z."xsd:string |
| http://purl.uniprot.org/citations/33159168 | http://purl.uniprot.org/core/author | "Bhardwaj N."xsd:string |
| http://purl.uniprot.org/citations/33159168 | http://purl.uniprot.org/core/author | "Merad M."xsd:string |
| http://purl.uniprot.org/citations/33159168 | http://purl.uniprot.org/core/author | "Lafaille J.J."xsd:string |
| http://purl.uniprot.org/citations/33159168 | http://purl.uniprot.org/core/author | "Kana V."xsd:string |
| http://purl.uniprot.org/citations/33159168 | http://purl.uniprot.org/core/author | "Turnbull D.H."xsd:string |
| http://purl.uniprot.org/citations/33159168 | http://purl.uniprot.org/core/author | "Tanne A."xsd:string |
| http://purl.uniprot.org/citations/33159168 | http://purl.uniprot.org/core/author | "Wojcinski A."xsd:string |
| http://purl.uniprot.org/citations/33159168 | http://purl.uniprot.org/core/author | "Tan I.L."xsd:string |
| http://purl.uniprot.org/citations/33159168 | http://purl.uniprot.org/core/author | "Sanghrajka R.M."xsd:string |
| http://purl.uniprot.org/citations/33159168 | http://purl.uniprot.org/core/author | "Arifa R.D.N."xsd:string |
| http://purl.uniprot.org/citations/33159168 | http://purl.uniprot.org/core/author | "Rallapalli H."xsd:string |
| http://purl.uniprot.org/citations/33159168 | http://purl.uniprot.org/core/author | "Sumru Bayin N."xsd:string |
| http://purl.uniprot.org/citations/33159168 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33159168 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/33159168 | http://purl.uniprot.org/core/pages | "396-407"xsd:string |
| http://purl.uniprot.org/citations/33159168 | http://purl.uniprot.org/core/title | "CSF1R inhibition depletes tumor-associated macrophages and attenuates tumor progression in a mouse sonic Hedgehog-Medulloblastoma model."xsd:string |
| http://purl.uniprot.org/citations/33159168 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/33159168 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33159168 |
| http://purl.uniprot.org/citations/33159168 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33159168 |