| http://purl.uniprot.org/citations/33168786 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33168786 | http://www.w3.org/2000/01/rdf-schema#comment | "Inflammation is known to play an important role in early brain injury (EBI) after subarachnoid hemorrhage (SAH). T cell immunoglobulin and mucin domain-3 (Tim-3) has emerged as a critical regulator of adaptive and innate immune responses, and has been identified to play a vital role in certain inflammatory diseases; The present study explored the effect of Tim-3 on inflammatory responses and detailed mechanism in EBI following SAH. We investigated the effects of Tim-3 on SAH models established by endovascular puncture method in Sprague-Dawley rats. The present studies revealed that SAH induced a significant inflammatory response and significantly increased Tim-3 expression. Tim-3-AAV administration aggravated neurocyte apoptosis, brain edema, blood-brain barrier permeability, and neurological dysfunction; significantly inhibited Nrf2 expression; and increased HMGB1 expression and secretion of pro-inflammatory cytokines, such as tumor necrosis factor alpha, interleukin (IL)-1 beta, IL-17, and IL-18. However, Tim-3 siRNA or NK252 administration abolished the pro-inflammatory effects of Tim-3. Our results indicate a function for Tim-3 as a molecular player that links neuroinflammation and brain damage after SAH. We reveal that Tim-3 overexpression deteriorates neuroinflammatory and neurocyte apoptosis after subarachnoid hemorrhage through the Nrf2/HMGB1 signaling pathway in rats."xsd:string |
| http://purl.uniprot.org/citations/33168786 | http://purl.org/dc/terms/identifier | "doi:10.18632/aging.103796"xsd:string |
| http://purl.uniprot.org/citations/33168786 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/33168786 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/33168786 | http://purl.uniprot.org/core/author | "Li R."xsd:string |
| http://purl.uniprot.org/citations/33168786 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/33168786 | http://purl.uniprot.org/core/author | "Guo S."xsd:string |
| http://purl.uniprot.org/citations/33168786 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/33168786 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/33168786 | http://purl.uniprot.org/core/author | "Wei B."xsd:string |
| http://purl.uniprot.org/citations/33168786 | http://purl.uniprot.org/core/author | "Cheng W."xsd:string |
| http://purl.uniprot.org/citations/33168786 | http://purl.uniprot.org/core/author | "Duan C."xsd:string |
| http://purl.uniprot.org/citations/33168786 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33168786 | http://purl.uniprot.org/core/name | "Aging (Albany NY)"xsd:string |
| http://purl.uniprot.org/citations/33168786 | http://purl.uniprot.org/core/pages | "21161-21185"xsd:string |
| http://purl.uniprot.org/citations/33168786 | http://purl.uniprot.org/core/title | "Tim-3 deteriorates neuroinflammatory and neurocyte apoptosis after subarachnoid hemorrhage through the Nrf2/HMGB1 signaling pathway in rats."xsd:string |
| http://purl.uniprot.org/citations/33168786 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/33168786 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33168786 |
| http://purl.uniprot.org/citations/33168786 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33168786 |
| http://purl.uniprot.org/uniprot/#_P0C0K5-mappedCitation-33168786 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33168786 |
| http://purl.uniprot.org/uniprot/P0C0K5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33168786 |