| http://purl.uniprot.org/citations/33175217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33175217 | http://www.w3.org/2000/01/rdf-schema#comment | "Little is known about genetic factors and mechanisms underlying shrimp allergy. Genome-wide association studies identified HLA class-II and IL13 genes as highly plausible candidates for shrimp allergy. The present study was designed to investigate potential associations of HLA-DQ rs9275596, IL13 rs20541, and IL13 rs1800925 polymorphisms with challenge-proven shrimp allergy using the data from 532 people of West Bengal, India; selected on basis of positive skin prick test, elevated specific IgE and medical history. Risk genotypes, i.e., HLA-DQ rs9275596 CC, IL13 rs20541 AA, and IL13 rs1800925 TT, were found to be significantly associated with challenge positive shrimp allergy (P = 0.04, 0.01, and 0.03, respectively). Distribution of genotypes for HLA-DQ and IL13 polymorphisms in allergic and control subjects showed significant difference between younger (20-40 years) and older (> 40 years) age group (P = 0.006). Risk genotypes significantly associated with elevated shrimp-specific IgE. IL13 TA haplotype significantly associated with shrimp allergy and elevated specific IgE (P = 0.02). Synergistic effect of IL13 TA haplotype-HLA-DQ rs9275596 CC genotype interaction significantly elevated specific IgE (P = 0.03). The present study suggests that HLA-DQ and IL13 polymorphisms pose major risk for shrimp allergic patients in West Bengal, India and thus could be helpful for early target-specific therapeutic intervention in near future."xsd:string |
| http://purl.uniprot.org/citations/33175217 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00251-020-01185-3"xsd:string |
| http://purl.uniprot.org/citations/33175217 | http://purl.uniprot.org/core/author | "Bhattacharya S."xsd:string |
| http://purl.uniprot.org/citations/33175217 | http://purl.uniprot.org/core/author | "Ghosh A."xsd:string |
| http://purl.uniprot.org/citations/33175217 | http://purl.uniprot.org/core/author | "Biswas H."xsd:string |
| http://purl.uniprot.org/citations/33175217 | http://purl.uniprot.org/core/author | "Saha G.K."xsd:string |
| http://purl.uniprot.org/citations/33175217 | http://purl.uniprot.org/core/author | "Podder S."xsd:string |
| http://purl.uniprot.org/citations/33175217 | http://purl.uniprot.org/core/author | "Moitra S."xsd:string |
| http://purl.uniprot.org/citations/33175217 | http://purl.uniprot.org/core/author | "Laha A."xsd:string |
| http://purl.uniprot.org/citations/33175217 | http://purl.uniprot.org/core/author | "Saha N.C."xsd:string |
| http://purl.uniprot.org/citations/33175217 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33175217 | http://purl.uniprot.org/core/name | "Immunogenetics"xsd:string |
| http://purl.uniprot.org/citations/33175217 | http://purl.uniprot.org/core/pages | "489-498"xsd:string |
| http://purl.uniprot.org/citations/33175217 | http://purl.uniprot.org/core/title | "Association of HLA-DQ and IL13 gene variants with challenge-proven shrimp allergy in West Bengal, India."xsd:string |
| http://purl.uniprot.org/citations/33175217 | http://purl.uniprot.org/core/volume | "72"xsd:string |
| http://purl.uniprot.org/citations/33175217 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33175217 |
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