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http://purl.uniprot.org/citations/33176218http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/33176218http://www.w3.org/2000/01/rdf-schema#comment"

Introduction

Severe eosinophilic asthma has been associated with Th2 airway inflammation and elevated proinflammatory cytokines and chemokines, such as IL-5. Precision therapies have recently been shown to improve asthma symptoms with a steroid-sparing effect. Two such therapies, Benralizumab and Mepolizumab, humanized IgG antibodies directed against the IL-5 receptor and IL-5, have been approved for severe eosinophilic asthma.

Methods

Here we used a differential proteomic approach to analyse serum from patients with severe eosinophilic asthma treated with Benralizumab and Mepolizumab in a search for differential molecular modifications responsible of their effects. Enrichment analysis of differential proteins was performed for the two treatments.

Results and discussion

After one month of Benralizumab treatment we detected up-regulation of certain protein species of the antioxidant ceruloplasmin. To investigate oxidative stress, we performed redox proteomics which detected lower oxidative burst after one month of Benralizumab treatment than in the pre-treatment phase or after one month of Mepolizumab therapy."xsd:string
http://purl.uniprot.org/citations/33176218http://purl.org/dc/terms/identifier"doi:10.1016/j.bbapap.2020.140563"xsd:string
http://purl.uniprot.org/citations/33176218http://purl.uniprot.org/core/author"Bini L."xsd:string
http://purl.uniprot.org/citations/33176218http://purl.uniprot.org/core/author"Angelucci S."xsd:string
http://purl.uniprot.org/citations/33176218http://purl.uniprot.org/core/author"Landi C."xsd:string
http://purl.uniprot.org/citations/33176218http://purl.uniprot.org/core/author"Bargagli E."xsd:string
http://purl.uniprot.org/citations/33176218http://purl.uniprot.org/core/author"Carleo A."xsd:string
http://purl.uniprot.org/citations/33176218http://purl.uniprot.org/core/author"Di Giuseppe F."xsd:string
http://purl.uniprot.org/citations/33176218http://purl.uniprot.org/core/author"Cameli P."xsd:string
http://purl.uniprot.org/citations/33176218http://purl.uniprot.org/core/author"Bergantini L."xsd:string
http://purl.uniprot.org/citations/33176218http://purl.uniprot.org/core/author"d'Alessandro M."xsd:string
http://purl.uniprot.org/citations/33176218http://purl.uniprot.org/core/author"Perruzza M."xsd:string
http://purl.uniprot.org/citations/33176218http://purl.uniprot.org/core/author"Shaba E."xsd:string
http://purl.uniprot.org/citations/33176218http://purl.uniprot.org/core/author"Vantaggiato L."xsd:string
http://purl.uniprot.org/citations/33176218http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/33176218http://purl.uniprot.org/core/name"Biochim Biophys Acta Proteins Proteom"xsd:string
http://purl.uniprot.org/citations/33176218http://purl.uniprot.org/core/pages"140563"xsd:string
http://purl.uniprot.org/citations/33176218http://purl.uniprot.org/core/title"Ceruloplasmin and oxidative stress in severe eosinophilic asthma patients treated with Mepolizumab and Benralizumab."xsd:string
http://purl.uniprot.org/citations/33176218http://purl.uniprot.org/core/volume"1869"xsd:string
http://purl.uniprot.org/citations/33176218http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/33176218
http://purl.uniprot.org/citations/33176218http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/33176218
http://purl.uniprot.org/uniprot/#_B3KTA8-mappedCitation-33176218http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/33176218
http://purl.uniprot.org/uniprot/#_A5PL27-mappedCitation-33176218http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/33176218
http://purl.uniprot.org/uniprot/#_B3IU76-mappedCitation-33176218http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/33176218
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