| http://purl.uniprot.org/citations/33190150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33190150 | http://www.w3.org/2000/01/rdf-schema#comment | "Patients with spinal muscular atrophy (SMA) are susceptible to the respiratory infections and might be at a heightened risk of poor clinical outcomes upon contracting coronavirus disease 2019 (COVID-19). In the face of the COVID-19 pandemic, the potential associations of SMA with the susceptibility to and prognostication of COVID-19 need to be clarified. We documented an SMA case who contracted COVID-19 but only developed mild-to-moderate clinical and radiological manifestations of pneumonia, which were relieved by a combined antiviral and supportive treatment. We then reviewed a cohort of patients with SMA who had been living in the Hubei province since November 2019, among which the only 1 out of 56 was diagnosed with COVID-19 (1.79%, 1/56). Bioinformatic analysis was carried out to delineate the potential genetic crosstalk between SMN1 (mutation of which leads to SMA) and COVID-19/lung injury-associated pathways. Protein-protein interaction analysis by STRING suggested that loss-of-function of SMN1 might modulate COVID-19 pathogenesis through CFTR, CXCL8, TNF and ACE. Expression quantitative trait loci analysis also revealed a link between SMN1 and ACE2, despite low-confidence protein-protein interactions as suggested by STRING. This bioinformatic analysis could give hint on why SMA might not necessarily lead to poor outcomes in patients with COVID-19."xsd:string |
| http://purl.uniprot.org/citations/33190150 | http://purl.org/dc/terms/identifier | "doi:10.1093/bib/bbaa285"xsd:string |
| http://purl.uniprot.org/citations/33190150 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/33190150 | http://purl.uniprot.org/core/author | "Jiao Y."xsd:string |
| http://purl.uniprot.org/citations/33190150 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/33190150 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/33190150 | http://purl.uniprot.org/core/author | "Liu G."xsd:string |
| http://purl.uniprot.org/citations/33190150 | http://purl.uniprot.org/core/author | "Lin Y."xsd:string |
| http://purl.uniprot.org/citations/33190150 | http://purl.uniprot.org/core/author | "Shen J."xsd:string |
| http://purl.uniprot.org/citations/33190150 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/33190150 | http://purl.uniprot.org/core/author | "Tan H."xsd:string |
| http://purl.uniprot.org/citations/33190150 | http://purl.uniprot.org/core/author | "Feng E."xsd:string |
| http://purl.uniprot.org/citations/33190150 | http://purl.uniprot.org/core/author | "Rong T."xsd:string |
| http://purl.uniprot.org/citations/33190150 | http://purl.uniprot.org/core/author | "Kei Wu W.K."xsd:string |
| http://purl.uniprot.org/citations/33190150 | http://purl.uniprot.org/core/author | "Vai Chan M.T."xsd:string |
| http://purl.uniprot.org/citations/33190150 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33190150 | http://purl.uniprot.org/core/name | "Brief Bioinform"xsd:string |
| http://purl.uniprot.org/citations/33190150 | http://purl.uniprot.org/core/pages | "1291-1296"xsd:string |
| http://purl.uniprot.org/citations/33190150 | http://purl.uniprot.org/core/title | "Bioinformatic analysis of SMN1-ACE/ACE2 interactions hinted at a potential protective effect of spinal muscular atrophy against COVID-19-induced lung injury."xsd:string |
| http://purl.uniprot.org/citations/33190150 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/33190150 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33190150 |
| http://purl.uniprot.org/citations/33190150 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33190150 |
| http://purl.uniprot.org/uniprot/#_A0A3G6V3P1-mappedCitation-33190150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33190150 |
| http://purl.uniprot.org/uniprot/#_A0A3G6V4Y6-mappedCitation-33190150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33190150 |