| http://purl.uniprot.org/citations/33200658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33200658 | http://www.w3.org/2000/01/rdf-schema#comment | "Unregulated Ca2+ influx affects intracellular Ca2+ homoeostasis, which may lead to neuronal death. In Drosophila, following the activation of rhodopsin the TRP Ca2+ channel is open to mediate the light-dependent depolarization. A constitutively active TRP channel triggers the degeneration of TrpP365 /+ photoreceptors. To explore retinal degeneration, we employed a multidisciplinary approach including live imaging using GFP tagged actin and arrestin 2. Importantly, we demonstrate that the major rhodopsin (Rh1) was greatly reduced before the onset of rhabdomere degeneration; a great reduction of Rh1 affects the maintenance of rhabdomere leading to degeneration of photoreceptors. TrpP365 /+ also led to the up-regulation of CaMKII, which is beneficial as suppression of CaMKII accelerated retinal degeneration. We explored the regulation of TRP by investigating the genetic interaction between TrpP365 /+ and mutants affecting the turnover of diacylglycerol (DAG). We show a loss of phospholipase C in norpAP24 exhibited a great reduction of the DAG content delayed degeneration of TrpP365 /+ photoreceptors. In contrast, knockdown or mutations in DAG lipase (InaE) that is accompanied by slightly reduced levels of most DAG but an increased level of DAG 34:1, exacerbated retinal degeneration of TrpP365 /+. Together, our findings support the notion that DAG plays a role in regulating TRP. Interestingly, DAG lipase is likely required during photoreceptor development as TrpP365 /+; inaEN125 double mutants contained severely degenerated rhabdomeres."xsd:string |
| http://purl.uniprot.org/citations/33200658 | http://purl.org/dc/terms/identifier | "doi:10.1080/19336934.2020.1851586"xsd:string |
| http://purl.uniprot.org/citations/33200658 | http://purl.uniprot.org/core/author | "Shieh B.H."xsd:string |
| http://purl.uniprot.org/citations/33200658 | http://purl.uniprot.org/core/author | "Kristaponyte I."xsd:string |
| http://purl.uniprot.org/citations/33200658 | http://purl.uniprot.org/core/author | "Nuzum L."xsd:string |
| http://purl.uniprot.org/citations/33200658 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33200658 | http://purl.uniprot.org/core/name | "Fly (Austin)"xsd:string |
| http://purl.uniprot.org/citations/33200658 | http://purl.uniprot.org/core/pages | "8-27"xsd:string |
| http://purl.uniprot.org/citations/33200658 | http://purl.uniprot.org/core/title | "Exploring Excitotoxicity and Regulation of a Constitutively Active TRP Ca2+ Channel in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/33200658 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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