| http://purl.uniprot.org/citations/33205021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33205021 | http://www.w3.org/2000/01/rdf-schema#comment | "TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) plays critical roles in B cells by promoting immunoglobulin class switching and plasma cell survival. However, its expression and function in T cells remain controversial. We show here that TACI expression can be strongly induced in murine CD4+ T cells in vitro by cytokines responsible for TH17 but not TH1 or TH2 differentiation. Frequencies and numbers of TH17 cells were elevated in TACI-/ - compared with wild-type mice as well as among TACI-/ - versus wild-type CD4+ T cells in mixed bone marrow chimeras, arguing for a T cell-intrinsic effect in the contribution of TACI deficiency to TH17 cell accumulation. TACI-/ - mice were more susceptible to severe colitis induced by dextran sodium sulfate or adoptive T cell transfer, suggesting that TACI negatively regulates TH17 function and limits intestinal inflammation in a cell-autonomous manner. Finally, transcriptomic and biochemical analyses revealed that TACI-/ - CD4+ T cells exhibited enhanced activation of TH17-promoting transcription factors NFAT, IRF4, c-MAF, and JUNB. Taken together, these findings reveal an important role of TACI in constraining TH17 pathogenicity and protecting against gut disease."xsd:string |
| http://purl.uniprot.org/citations/33205021 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.isci.2020.101707"xsd:string |
| http://purl.uniprot.org/citations/33205021 | http://purl.uniprot.org/core/author | "Zhang B."xsd:string |
| http://purl.uniprot.org/citations/33205021 | http://purl.uniprot.org/core/author | "Xu S."xsd:string |
| http://purl.uniprot.org/citations/33205021 | http://purl.uniprot.org/core/author | "Kim S.S."xsd:string |
| http://purl.uniprot.org/citations/33205021 | http://purl.uniprot.org/core/author | "Ou X."xsd:string |
| http://purl.uniprot.org/citations/33205021 | http://purl.uniprot.org/core/author | "Lee A.P."xsd:string |
| http://purl.uniprot.org/citations/33205021 | http://purl.uniprot.org/core/author | "Ng S.W."xsd:string |
| http://purl.uniprot.org/citations/33205021 | http://purl.uniprot.org/core/author | "Lam K.P."xsd:string |
| http://purl.uniprot.org/citations/33205021 | http://purl.uniprot.org/core/author | "Tan A.H."xsd:string |
| http://purl.uniprot.org/citations/33205021 | http://purl.uniprot.org/core/author | "Sanny A."xsd:string |
| http://purl.uniprot.org/citations/33205021 | http://purl.uniprot.org/core/author | "Teo P.Y."xsd:string |
| http://purl.uniprot.org/citations/33205021 | http://purl.uniprot.org/core/author | "Tan S.J.X."xsd:string |
| http://purl.uniprot.org/citations/33205021 | http://purl.uniprot.org/core/author | "Tso G.H.W."xsd:string |
| http://purl.uniprot.org/citations/33205021 | http://purl.uniprot.org/core/author | "Wong A.X.F."xsd:string |
| http://purl.uniprot.org/citations/33205021 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33205021 | http://purl.uniprot.org/core/name | "iScience"xsd:string |
| http://purl.uniprot.org/citations/33205021 | http://purl.uniprot.org/core/pages | "101707"xsd:string |
| http://purl.uniprot.org/citations/33205021 | http://purl.uniprot.org/core/title | "TACI Constrains TH17 Pathogenicity and Protects against Gut Inflammation."xsd:string |
| http://purl.uniprot.org/citations/33205021 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/33205021 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33205021 |
| http://purl.uniprot.org/citations/33205021 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33205021 |
| http://purl.uniprot.org/uniprot/#_A5D8Y6-mappedCitation-33205021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33205021 |
| http://purl.uniprot.org/uniprot/#_A5D8Y7-mappedCitation-33205021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33205021 |