| http://purl.uniprot.org/citations/33216373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33216373 | http://www.w3.org/2000/01/rdf-schema#comment | "Sickle cell disease (SCD) and apolipoprotein L1 (APOL1) G1/G2 variants increase chronic kidney disease (CKD) risk in African Americans by poorly understood mechanisms. We applied bioinformatics to identify new candidate genes associated with SCD-related CKD. An interaction network demonstrated APOA1 connecting haemoglobin subunit β (HBB) and APOL1 with 36 other candidate genes. Gene expression revealed upregulation of engulfment and cell motility 1 (ELMO1) and downregulation of APOA1 in the kidney cortex of SCD versus non-SCD mice. Analysis of candidate genes identified ELMO1 rs10951509 to be associated with albuminuria and APOA1 rs11216132 with haemoglobinuria in patients with SCD. A bioinformatic approach highlights ELMO1 and APOA1 as potentially associated with SCD nephropathy."xsd:string |
| http://purl.uniprot.org/citations/33216373 | http://purl.org/dc/terms/identifier | "doi:10.1111/bjh.17224"xsd:string |
| http://purl.uniprot.org/citations/33216373 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/33216373 | http://purl.uniprot.org/core/author | "Franceschini N."xsd:string |
| http://purl.uniprot.org/citations/33216373 | http://purl.uniprot.org/core/author | "Gordeuk V.R."xsd:string |
| http://purl.uniprot.org/citations/33216373 | http://purl.uniprot.org/core/author | "Shah B.N."xsd:string |
| http://purl.uniprot.org/citations/33216373 | http://purl.uniprot.org/core/author | "Tayo B.O."xsd:string |
| http://purl.uniprot.org/citations/33216373 | http://purl.uniprot.org/core/author | "Lash J.P."xsd:string |
| http://purl.uniprot.org/citations/33216373 | http://purl.uniprot.org/core/author | "Saraf S.L."xsd:string |
| http://purl.uniprot.org/citations/33216373 | http://purl.uniprot.org/core/author | "Raslan R."xsd:string |
| http://purl.uniprot.org/citations/33216373 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33216373 | http://purl.uniprot.org/core/name | "Br J Haematol"xsd:string |
| http://purl.uniprot.org/citations/33216373 | http://purl.uniprot.org/core/pages | "628-632"xsd:string |
| http://purl.uniprot.org/citations/33216373 | http://purl.uniprot.org/core/title | "Engulfment and cell motility 1 (ELMO1) and apolipoprotein A1 (APOA1) as candidate genes for sickle cell nephropathy."xsd:string |
| http://purl.uniprot.org/citations/33216373 | http://purl.uniprot.org/core/volume | "193"xsd:string |
| http://purl.uniprot.org/citations/33216373 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33216373 |
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| http://purl.uniprot.org/uniprot/#_P02647-mappedCitation-33216373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33216373 |