| http://purl.uniprot.org/citations/33219221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33219221 | http://www.w3.org/2000/01/rdf-schema#comment | "Adrenocortical carcinoma is one of the aggressive malignancies and it originates from the cortex of adrenal gland. Dysregulation of long non-coding RNA plays important roles in the development of adrenocortical carcinoma. Here, we found that lncRNA ASB16-AS1 was down-regulated in adrenocortical carcinoma and ASB16-AS1 functions as tumor suppressor in vitro and in vivo. We then found that IGF1R and CDK6 are regulated by ASB16-AS1 in adrenocortical carcinoma cells by transcriptome RNA sequencing. ASB16-AS1 associates with RNA-binding protein HuR (ELAVL1) as revealed by RNA pull-down following mass spectrometry. Also, ASB16-AS1 inhibits HuR expression post-translationally by promoting its ubiquitination. ASB16-AS1 regulates IGF1R and CDK6 mRNA expression through RNA-binding protein HuR. We then found that inhibition of ASB16-AS1 attenuates the binding of ubiquitin E3 ligase BTRC to HuR and subsequently inhibits HuR protein unbiquitination and degradation. BTRC knock-down could reverse the effect of AB16-AS1 on HuR, CDK6, and IGF1R levels. Collectively, these results demonstrate that ASB16-AS1 regulates adrenocortical carcinoma cell proliferation and tackling the level of ASB16-AS1 may be developed to treat adrenocortical carcinoma."xsd:string |
| http://purl.uniprot.org/citations/33219221 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41419-020-03205-2"xsd:string |
| http://purl.uniprot.org/citations/33219221 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/33219221 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/33219221 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/33219221 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/33219221 | http://purl.uniprot.org/core/author | "Xu X."xsd:string |
| http://purl.uniprot.org/citations/33219221 | http://purl.uniprot.org/core/author | "Xu X.'"xsd:string |
| http://purl.uniprot.org/citations/33219221 | http://purl.uniprot.org/core/author | "Long B."xsd:string |
| http://purl.uniprot.org/citations/33219221 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33219221 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/33219221 | http://purl.uniprot.org/core/pages | "995"xsd:string |
| http://purl.uniprot.org/citations/33219221 | http://purl.uniprot.org/core/title | "Long noncoding RNA ASB16-AS1 inhibits adrenocortical carcinoma cell growth by promoting ubiquitination of RNA-binding protein HuR."xsd:string |
| http://purl.uniprot.org/citations/33219221 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/33219221 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33219221 |
| http://purl.uniprot.org/citations/33219221 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33219221 |
| http://purl.uniprot.org/uniprot/#_B3KP44-mappedCitation-33219221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33219221 |
| http://purl.uniprot.org/uniprot/#_I6L964-mappedCitation-33219221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33219221 |
| http://purl.uniprot.org/uniprot/#_Q15717-mappedCitation-33219221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33219221 |
| http://purl.uniprot.org/uniprot/#_Q495Z4-mappedCitation-33219221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33219221 |
| http://purl.uniprot.org/uniprot/I6L964 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33219221 |
| http://purl.uniprot.org/uniprot/Q495Z4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33219221 |
| http://purl.uniprot.org/uniprot/Q15717 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33219221 |
| http://purl.uniprot.org/uniprot/B3KP44 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33219221 |