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http://purl.uniprot.org/citations/33219495http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/33219495http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

Dynamin-related protein 1 (DRP1), a mitochondrial fission protein, and its active form phosphorylated at Serine 616 (S616-p-DRP1) have been increasingly associated with tumorigenesis and invasion in various tumor models, including oncocytic thyroid cancer (TC). In this study, the expression of DRP1 and S616-p-DRP1 and its relationship with patients' clinicopathological characteristics, tumor genetic profiles, and clinical outcomes were assessed in a large series of follicular cell-derived TC (FCDTC).

Methods

Retrospective biomarker study characterizing the clinicopathological and immunochemistry DRP1 and S616-p-DRP1 expression of a series of 259 patients with FCDTC followed in two University Hospitals.

Results

DRP1 expression was positive in 65.3% (169/259) of the cases, while the expression of the S616-p-DRP1 was positive in only 17.3% (17/98). DRP1-positive expression was significantly associated with differentiated tumors (67.7 vs. 48.0%; P = 0.049), non-encapsulated tumors (73.8 vs. 57.4%; P = 0.011) and thyroid capsule invasion (73.4 vs. 57.5%; P = 0.013). S616-p-DRP1-positive expression was significantly associated with tumor infiltrative margins (88.9 vs. 11.1%; P = 0.033), thyroid capsule invasion (29.8 vs. 3.1%; P = 0.043), lymph node metastases (23.3 vs. 8.1%; P = 0.012), and higher mean cumulative radioiodine dosage (317.4 ± 265.0 mCi vs. 202.5 ± 217.7 mCi; P = 0.038). S616-p-DRP1 expression was negatively associated with oncocytic phenotype (0.0 vs. 26.2%; P = 0.028).

Conclusions

S616-p-DRP1 is a better candidate than DRP1 to identify tumors with locally invasive behavior. Prospective studies should be pursued to assess S616-p-DRP1 role as a molecular marker of malignancy in TC and in patients' risk assessment."xsd:string
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http://purl.uniprot.org/citations/33219495http://purl.uniprot.org/core/author"Correia M."xsd:string
http://purl.uniprot.org/citations/33219495http://purl.uniprot.org/core/author"Rios E."xsd:string
http://purl.uniprot.org/citations/33219495http://purl.uniprot.org/core/author"Soares P."xsd:string
http://purl.uniprot.org/citations/33219495http://purl.uniprot.org/core/author"Sobrinho-Simoes M."xsd:string
http://purl.uniprot.org/citations/33219495http://purl.uniprot.org/core/author"Santos L."xsd:string
http://purl.uniprot.org/citations/33219495http://purl.uniprot.org/core/author"Lima A.R."xsd:string
http://purl.uniprot.org/citations/33219495http://purl.uniprot.org/core/author"Maximo V."xsd:string
http://purl.uniprot.org/citations/33219495http://purl.uniprot.org/core/author"Melo M."xsd:string
http://purl.uniprot.org/citations/33219495http://purl.uniprot.org/core/author"Tavares C."xsd:string
http://purl.uniprot.org/citations/33219495http://purl.uniprot.org/core/author"Canberk S."xsd:string
http://purl.uniprot.org/citations/33219495http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/33219495http://purl.uniprot.org/core/name"Endocrine"xsd:string
http://purl.uniprot.org/citations/33219495http://purl.uniprot.org/core/pages"85-97"xsd:string
http://purl.uniprot.org/citations/33219495http://purl.uniprot.org/core/title"S616-p-DRP1 associates with locally invasive behavior of follicular cell-derived thyroid carcinoma."xsd:string
http://purl.uniprot.org/citations/33219495http://purl.uniprot.org/core/volume"73"xsd:string
http://purl.uniprot.org/citations/33219495http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/33219495
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