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Background

The relationships among serum Apelin, Asymmetric-dimethylarginine (ADMA), N-terminal probrain natriureticpeptide (NT-proBNP) levels, and blood pressures in dialysis patients are not well known.

Materials and methods

Age and sex matched 30 hemodialysis (HD), 30 peritoneal dialysis (PD) patients, and 20 healthy controls were recruited. Serum apelin-36, ADMA, NT-proBNP levels, and blood pressures of both patients and healthy controls were measured and compared.

Results

Serum ADMA and Apelin levels in HD patients were significantly higher than in PD patients. In multiple regression analyses the predictors of higher serum apelin levels were higher BMI, higher ADMA and lower systolic blood pressure. The predictors of serum ADMA levels were being on HD. The predictors of serum NT-proBNP levels were lower serum albumin and higher systolic blood pressure.

Conclusion

Being on HD is a predictor of high ADMA levels. HD might be less effective on ADMA removal than PD. It seems that higher serum apelin levels related with lower sytolic blood pressure levels, whereas higher NT-proBNP levels related with higher sytolic blood pressure levels indicating potential roles as independent prognostic factors for systolic hypertension in dialysis patients."xsd:string
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http://purl.uniprot.org/citations/33221779http://purl.uniprot.org/core/author"Dogan A."xsd:string
http://purl.uniprot.org/citations/33221779http://purl.uniprot.org/core/author"Taskapan H."xsd:string
http://purl.uniprot.org/citations/33221779http://purl.uniprot.org/core/author"Taskapan M.C."xsd:string
http://purl.uniprot.org/citations/33221779http://purl.uniprot.org/core/author"Bentli R."xsd:string
http://purl.uniprot.org/citations/33221779http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/33221779http://purl.uniprot.org/core/name"Niger J Clin Pract"xsd:string
http://purl.uniprot.org/citations/33221779http://purl.uniprot.org/core/pages"1542-1547"xsd:string
http://purl.uniprot.org/citations/33221779http://purl.uniprot.org/core/title"Serum asymmetric-dimethylarginine, apelin and NT-pro BNP levels in dialysis patients."xsd:string
http://purl.uniprot.org/citations/33221779http://purl.uniprot.org/core/volume"23"xsd:string
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