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http://purl.uniprot.org/citations/33235068http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/33235068http://www.w3.org/2000/01/rdf-schema#comment"

Background

This study meta-analyzed the literature on possible association of 3 polymorphisms (-592, -1082, -819) in the interleukin-10 (IL-10) gene with susceptibility to human immunodeficiency virus (HIV)-1 infection.

Methods

PubMed, EMBASE, MEDLINE and Google Scholar were systematically searched to identify relevant studies in English. Meta-analyses were performed to examine the association of IL-10 polymorphisms -592, -1082, and -819 with susceptibility to HIV-1 infection.

Results

A significant association between the -592 polymorphism and susceptibility to HIV-1 infection was found in the total population (recessive model, odds ratios (OR) = 1.44, 95% CI = 1.06-1.96, P = .02; homozygous model, OR = 1.44, 95% CI = 1.02-2.02, P = .04). However, these results were not observed in subgroups based on ethnicity. The -1082 polymorphism was significantly associated with susceptibility to HIV-1 infection in Caucasians (OR = 1.30, 95% CI = 1.05-1.62, P = .02; recessive model, OR = 1.49, 95% CI = 1.09-2.03, P = .01; homozygous model, OR = 1.58, 95% CI = 1.01-2.46, P = .04), but not in Asians or the total population. None of the 5 genetic models suggested a significant association between the -819 polymorphism and HIV-1 infection.

Conclusion

The available evidence indicates that the AA genotype of IL-10 -592 may confer increased susceptibility to HIV-1 infection, and that the AA genotype of -1082 may confer increased susceptibility in Caucasians. In contrast, the -819 polymorphism may not be associated with HIV-1 infection risk. These conclusions should be verified in large, well-designed studies."xsd:string
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http://purl.uniprot.org/citations/33235068http://purl.uniprot.org/core/author"Chen J."xsd:string
http://purl.uniprot.org/citations/33235068http://purl.uniprot.org/core/author"Hong S."xsd:string
http://purl.uniprot.org/citations/33235068http://purl.uniprot.org/core/author"Yang Z."xsd:string
http://purl.uniprot.org/citations/33235068http://purl.uniprot.org/core/author"Zhao Y."xsd:string
http://purl.uniprot.org/citations/33235068http://purl.uniprot.org/core/author"Ding Q.L."xsd:string
http://purl.uniprot.org/citations/33235068http://purl.uniprot.org/core/author"Fu D.H."xsd:string
http://purl.uniprot.org/citations/33235068http://purl.uniprot.org/core/author"Deng W.J."xsd:string
http://purl.uniprot.org/citations/33235068http://purl.uniprot.org/core/author"Su D.K."xsd:string
http://purl.uniprot.org/citations/33235068http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/33235068http://purl.uniprot.org/core/name"Medicine (Baltimore)"xsd:string
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http://purl.uniprot.org/citations/33235068http://purl.uniprot.org/core/title"Association between polymorphisms in the interleukin-10 gene and susceptibility to human immunodeficiency virus-1 infection: A systematic review and meta-analysis."xsd:string
http://purl.uniprot.org/citations/33235068http://purl.uniprot.org/core/volume"99"xsd:string
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