| http://purl.uniprot.org/citations/33235205 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33235205 | http://www.w3.org/2000/01/rdf-schema#comment | "The abuse potential of ketamine limits its clinical application, but the precise mechanism remains largely unclear. Here we discovered that ketamine significantly remodels the endocannabinoid-related lipidome and activates 2-arachidonoylglycerol (2-AG) signaling in the dorsal striatum (caudate nucleus and putamen, CPu) of mice. Elevated 2-AG in the CPu is essential for the psychostimulant and reinforcing effects of ketamine, whereas blockade of the cannabinoid CB1 receptor, a predominant 2-AG receptor, attenuates ketamine-induced remodeling of neuronal dendrite structure and neurobehaviors. Ketamine represses the transcription of the monoacylglycerol lipase (MAGL) gene by promoting the expression of PRDM5, a negative transcription factor of the MAGL gene, leading to increased 2-AG production. Genetic overexpression of MAGL or silencing of PRDM5 expression in the CPu robustly reduces 2-AG production and ketamine effects. Collectively, endocannabinoid signaling plays a critical role in mediating the psychostimulant and reinforcing properties of ketamine."xsd:string |
| http://purl.uniprot.org/citations/33235205 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-19780-z"xsd:string |
| http://purl.uniprot.org/citations/33235205 | http://purl.uniprot.org/core/author | "Fang Q."xsd:string |
| http://purl.uniprot.org/citations/33235205 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/33235205 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/33235205 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/33235205 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/33235205 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
| http://purl.uniprot.org/citations/33235205 | http://purl.uniprot.org/core/author | "Xiao Y."xsd:string |
| http://purl.uniprot.org/citations/33235205 | http://purl.uniprot.org/core/author | "Tian J."xsd:string |
| http://purl.uniprot.org/citations/33235205 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/33235205 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/33235205 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/33235205 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/33235205 | http://purl.uniprot.org/core/author | "Wan X."xsd:string |
| http://purl.uniprot.org/citations/33235205 | http://purl.uniprot.org/core/author | "Bu Q."xsd:string |
| http://purl.uniprot.org/citations/33235205 | http://purl.uniprot.org/core/author | "Cen X."xsd:string |
| http://purl.uniprot.org/citations/33235205 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33235205 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/33235205 | http://purl.uniprot.org/core/pages | "5962"xsd:string |
| http://purl.uniprot.org/citations/33235205 | http://purl.uniprot.org/core/title | "Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice."xsd:string |
| http://purl.uniprot.org/citations/33235205 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/33235205 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33235205 |
| http://purl.uniprot.org/citations/33235205 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33235205 |