| http://purl.uniprot.org/citations/33236530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33236530 | http://www.w3.org/2000/01/rdf-schema#comment | "Gallbladder carcinoma (GBC) commonly occurs in gastrointestinal malignancy and has the fifth highest mortality rate among gastrointestinal malignancy. Recently, miR-188-5p, a small noncoding RNA, has been implicated in various types of cancer such as nasopharyngeal carcinoma, oral squamous cell carcinoma, liver cancer, and prostate cancer. However, the effect of miR-188-5p on GBC remains unclear. Here, we demonstrated that miR-188-5p was downregulated in GBC tissues, and downregulation of miR-188-5p correlated with larger tumor size, lymph node metastasis, and extensive metastasis. In addition, the overall survival time of patients with higher miR-188-5p expression was significantly longer than that of patients with low-miR-188-5p expression. Moreover, downregulation of miR-188-5p promoted the proliferation, migration, and invasion of GBC cells, while its overexpression inhibited cell invasion and induced cell apoptosis, and arrested GBC growth in vivo. Importantly, miR-188-5p-dependent tumorigenesis was correlated with Wnt/β-catenin signaling and p-38/JNK signaling. In conclusion, miR-188-5p plays a direct role in GBC tumorigenesis. Our study suggests that miR-188-5p could serve as a novel diagnosis marker and therapeutic target in GBC."xsd:string |
| http://purl.uniprot.org/citations/33236530 | http://purl.org/dc/terms/identifier | "doi:10.1002/kjm2.12323"xsd:string |
| http://purl.uniprot.org/citations/33236530 | http://purl.uniprot.org/core/author | "Li X.L."xsd:string |
| http://purl.uniprot.org/citations/33236530 | http://purl.uniprot.org/core/author | "Li S.Z."xsd:string |
| http://purl.uniprot.org/citations/33236530 | http://purl.uniprot.org/core/author | "Wu C.X."xsd:string |
| http://purl.uniprot.org/citations/33236530 | http://purl.uniprot.org/core/author | "Xing X.H."xsd:string |
| http://purl.uniprot.org/citations/33236530 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33236530 | http://purl.uniprot.org/core/name | "Kaohsiung J Med Sci"xsd:string |
| http://purl.uniprot.org/citations/33236530 | http://purl.uniprot.org/core/pages | "294-304"xsd:string |
| http://purl.uniprot.org/citations/33236530 | http://purl.uniprot.org/core/title | "miR-188-5p inhibits proliferation, migration, and invasion in gallbladder carcinoma by targeting Wnt2b and Smad2."xsd:string |
| http://purl.uniprot.org/citations/33236530 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/33236530 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33236530 |
| http://purl.uniprot.org/citations/33236530 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33236530 |
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| http://purl.uniprot.org/uniprot/#_Q15796-mappedCitation-33236530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33236530 |
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| http://purl.uniprot.org/uniprot/#_Q93097-mappedCitation-33236530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33236530 |
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| http://purl.uniprot.org/uniprot/Q15796 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33236530 |
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