http://purl.uniprot.org/citations/33239640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/33239640 | http://www.w3.org/2000/01/rdf-schema#comment | "Intracellular traffic between compartments of the secretory and endocytic pathways is mediated by vesicle-based carriers. The proteomes of carriers destined for many organelles are ill-defined because the vesicular intermediates are transient, low-abundance and difficult to purify. Here, we combine vesicle relocalisation with organelle proteomics and Bayesian analysis to define the content of different endosome-derived vesicles destined for the trans-Golgi network (TGN). The golgin coiled-coil proteins golgin-97 and GCC88, shown previously to capture endosome-derived vesicles at the TGN, were individually relocalised to mitochondria and the content of the subsequently re-routed vesicles was determined by organelle proteomics. Our findings reveal 45 integral and 51 peripheral membrane proteins re-routed by golgin-97, evidence for a distinct class of vesicles shared by golgin-97 and GCC88, and various cargoes specific to individual golgins. These results illustrate a general strategy for analysing intracellular sub-proteomes by combining acute cellular re-wiring with high-resolution spatial proteomics."xsd:string |
http://purl.uniprot.org/citations/33239640 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-19840-4"xsd:string |
http://purl.uniprot.org/citations/33239640 | http://purl.uniprot.org/core/author | "Peak-Chew S.Y."xsd:string |
http://purl.uniprot.org/citations/33239640 | http://purl.uniprot.org/core/author | "Shin J.J.H."xsd:string |
http://purl.uniprot.org/citations/33239640 | http://purl.uniprot.org/core/author | "Lilley K.S."xsd:string |
http://purl.uniprot.org/citations/33239640 | http://purl.uniprot.org/core/author | "Munro S."xsd:string |
http://purl.uniprot.org/citations/33239640 | http://purl.uniprot.org/core/author | "Gillingham A.K."xsd:string |
http://purl.uniprot.org/citations/33239640 | http://purl.uniprot.org/core/author | "Cattin-Ortola J."xsd:string |
http://purl.uniprot.org/citations/33239640 | http://purl.uniprot.org/core/author | "Chadwick J."xsd:string |
http://purl.uniprot.org/citations/33239640 | http://purl.uniprot.org/core/author | "Breckels L.M."xsd:string |
http://purl.uniprot.org/citations/33239640 | http://purl.uniprot.org/core/author | "Borgeaud A.C."xsd:string |
http://purl.uniprot.org/citations/33239640 | http://purl.uniprot.org/core/author | "Crook O.M."xsd:string |
http://purl.uniprot.org/citations/33239640 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
http://purl.uniprot.org/citations/33239640 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
http://purl.uniprot.org/citations/33239640 | http://purl.uniprot.org/core/pages | "5987"xsd:string |
http://purl.uniprot.org/citations/33239640 | http://purl.uniprot.org/core/title | "Spatial proteomics defines the content of trafficking vesicles captured by golgin tethers."xsd:string |
http://purl.uniprot.org/citations/33239640 | http://purl.uniprot.org/core/volume | "11"xsd:string |
http://purl.uniprot.org/citations/33239640 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33239640 |
http://purl.uniprot.org/citations/33239640 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33239640 |
http://purl.uniprot.org/uniprot/#_A4D0Z4-mappedCitation-33239640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33239640 |
http://purl.uniprot.org/uniprot/#_B2RDB1-mappedCitation-33239640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33239640 |
http://purl.uniprot.org/uniprot/#_B3KS56-mappedCitation-33239640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33239640 |
http://purl.uniprot.org/uniprot/#_B4DYI0-mappedCitation-33239640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33239640 |
http://purl.uniprot.org/uniprot/#_Q59HA1-mappedCitation-33239640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33239640 |