| http://purl.uniprot.org/citations/33242395 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33242395 | http://www.w3.org/2000/01/rdf-schema#comment | "αβ lineage T cells, most of which are CD4+ or CD8+ and recognize MHC I- or MHC II-presented antigens, are essential for immune responses and develop from CD4+CD8+ thymocytes. The absence of in vitro models and the heterogeneity of αβ thymocytes have hampered analyses of their intrathymic differentiation. Here, combining single-cell RNA and ATAC (chromatin accessibility) sequencing, we identified mouse and human αβ thymocyte developmental trajectories. We demonstrated asymmetric emergence of CD4+ and CD8+ lineages, matched differentiation programs of agonist-signaled cells to their MHC specificity, and identified correspondences between mouse and human transcriptomic and epigenomic patterns. Through computational analysis of single-cell data and binding sites for the CD4+-lineage transcription factor Thpok, we inferred transcriptional networks associated with CD4+- or CD8+-lineage differentiation, and with expression of Thpok or of the CD8+-lineage factor Runx3. Our findings provide insight into the mechanisms of CD4+ and CD8+ T cell differentiation and a foundation for mechanistic investigations of αβ T cell development."xsd:string |
| http://purl.uniprot.org/citations/33242395 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2020.10.024"xsd:string |
| http://purl.uniprot.org/citations/33242395 | http://purl.uniprot.org/core/author | "Gao Y."xsd:string |
| http://purl.uniprot.org/citations/33242395 | http://purl.uniprot.org/core/author | "Hannenhalli S."xsd:string |
| http://purl.uniprot.org/citations/33242395 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/33242395 | http://purl.uniprot.org/core/author | "Gopalan V."xsd:string |
| http://purl.uniprot.org/citations/33242395 | http://purl.uniprot.org/core/author | "Livak F."xsd:string |
| http://purl.uniprot.org/citations/33242395 | http://purl.uniprot.org/core/author | "Bosticardo M."xsd:string |
| http://purl.uniprot.org/citations/33242395 | http://purl.uniprot.org/core/author | "Pala F."xsd:string |
| http://purl.uniprot.org/citations/33242395 | http://purl.uniprot.org/core/author | "Bosselut R."xsd:string |
| http://purl.uniprot.org/citations/33242395 | http://purl.uniprot.org/core/author | "Kelly M.C."xsd:string |
| http://purl.uniprot.org/citations/33242395 | http://purl.uniprot.org/core/author | "Lagarde M."xsd:string |
| http://purl.uniprot.org/citations/33242395 | http://purl.uniprot.org/core/author | "Rae Z."xsd:string |
| http://purl.uniprot.org/citations/33242395 | http://purl.uniprot.org/core/author | "Ciucci T."xsd:string |
| http://purl.uniprot.org/citations/33242395 | http://purl.uniprot.org/core/author | "Chopp L.B."xsd:string |
| http://purl.uniprot.org/citations/33242395 | http://purl.uniprot.org/core/author | "Ruchinskas A."xsd:string |
| http://purl.uniprot.org/citations/33242395 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33242395 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/33242395 | http://purl.uniprot.org/core/pages | "1182-1201.e8"xsd:string |
| http://purl.uniprot.org/citations/33242395 | http://purl.uniprot.org/core/title | "An Integrated Epigenomic and Transcriptomic Map of Mouse and Human alphabeta T Cell Development."xsd:string |
| http://purl.uniprot.org/citations/33242395 | http://purl.uniprot.org/core/volume | "53"xsd:string |
| http://purl.uniprot.org/citations/33242395 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33242395 |
| http://purl.uniprot.org/citations/33242395 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33242395 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-33242395 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33242395 |