| http://purl.uniprot.org/citations/33243850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33243850 | http://www.w3.org/2000/01/rdf-schema#comment | "Factor-dependent transcription termination mechanisms are poorly understood. We determined a series of cryo-electron microscopy structures portraying the hexameric adenosine triphosphatase (ATPase) ρ on a pathway to terminating NusA/NusG-modified elongation complexes. An open ρ ring contacts NusA, NusG, and multiple regions of RNA polymerase, trapping and locally unwinding proximal upstream DNA. NusA wedges into the ρ ring, initially sequestering RNA. Upon deflection of distal upstream DNA over the RNA polymerase zinc-binding domain, NusA rotates underneath one capping ρ subunit, which subsequently captures RNA. After detachment of NusG and clamp opening, RNA polymerase loses its grip on the RNA:DNA hybrid and is inactivated. Our structural and functional analyses suggest that ρ, and other termination factors across life, may use analogous strategies to allosterically trap transcription complexes in a moribund state."xsd:string |
| http://purl.uniprot.org/citations/33243850 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.abd1673"xsd:string |
| http://purl.uniprot.org/citations/33243850 | http://purl.uniprot.org/core/author | "Belogurov G.A."xsd:string |
| http://purl.uniprot.org/citations/33243850 | http://purl.uniprot.org/core/author | "Wahl M.C."xsd:string |
| http://purl.uniprot.org/citations/33243850 | http://purl.uniprot.org/core/author | "Burger J."xsd:string |
| http://purl.uniprot.org/citations/33243850 | http://purl.uniprot.org/core/author | "Khatri A."xsd:string |
| http://purl.uniprot.org/citations/33243850 | http://purl.uniprot.org/core/author | "Artsimovitch I."xsd:string |
| http://purl.uniprot.org/citations/33243850 | http://purl.uniprot.org/core/author | "Loll B."xsd:string |
| http://purl.uniprot.org/citations/33243850 | http://purl.uniprot.org/core/author | "Sen R."xsd:string |
| http://purl.uniprot.org/citations/33243850 | http://purl.uniprot.org/core/author | "Hilal T."xsd:string |
| http://purl.uniprot.org/citations/33243850 | http://purl.uniprot.org/core/author | "Mielke T."xsd:string |
| http://purl.uniprot.org/citations/33243850 | http://purl.uniprot.org/core/author | "Said N."xsd:string |
| http://purl.uniprot.org/citations/33243850 | http://purl.uniprot.org/core/author | "Sunday N.D."xsd:string |
| http://purl.uniprot.org/citations/33243850 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33243850 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/33243850 | http://purl.uniprot.org/core/pages | "eabd1673"xsd:string |
| http://purl.uniprot.org/citations/33243850 | http://purl.uniprot.org/core/title | "Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase rho."xsd:string |
| http://purl.uniprot.org/citations/33243850 | http://purl.uniprot.org/core/volume | "371"xsd:string |
| http://purl.uniprot.org/citations/33243850 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33243850 |
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| http://purl.uniprot.org/uniprot/#_P0A7Z4-mappedCitation-33243850 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33243850 |