| http://purl.uniprot.org/citations/33243860 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33243860 | http://www.w3.org/2000/01/rdf-schema#comment | "The 14-subunit metazoan-specific Integrator contains an endonuclease that cleaves nascent RNA transcripts. Here, we identified a complex containing Integrator and protein phosphatase 2A core enzyme (PP2A-AC), termed INTAC. The 3.5-angstrom-resolution structure reveals that nine human Integrator subunits and PP2A-AC assemble into a cruciform-shaped central scaffold formed by the backbone and shoulder modules, with the phosphatase and endonuclease modules flanking the opposite sides. As a noncanonical PP2A holoenzyme, the INTAC complex dephosphorylates the carboxy-terminal repeat domain of RNA polymerase II at serine-2, -5, and -7 and thus regulates transcription. Our study extends the function of PP2A to transcriptional regulation and reveals how dual enzymatic activities-RNA cleavage and RNA polymerase II dephosphorylation-are structurally and functionally integrated into the INTAC complex."xsd:string |
| http://purl.uniprot.org/citations/33243860 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.abb5872"xsd:string |
| http://purl.uniprot.org/citations/33243860 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/33243860 | http://purl.uniprot.org/core/author | "Cao X."xsd:string |
| http://purl.uniprot.org/citations/33243860 | http://purl.uniprot.org/core/author | "Hu S."xsd:string |
| http://purl.uniprot.org/citations/33243860 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/33243860 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/33243860 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/33243860 | http://purl.uniprot.org/core/author | "Liang K."xsd:string |
| http://purl.uniprot.org/citations/33243860 | http://purl.uniprot.org/core/author | "Qi Y."xsd:string |
| http://purl.uniprot.org/citations/33243860 | http://purl.uniprot.org/core/author | "Wei G."xsd:string |
| http://purl.uniprot.org/citations/33243860 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/33243860 | http://purl.uniprot.org/core/author | "Xu C."xsd:string |
| http://purl.uniprot.org/citations/33243860 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/33243860 | http://purl.uniprot.org/core/author | "Zheng H."xsd:string |
| http://purl.uniprot.org/citations/33243860 | http://purl.uniprot.org/core/author | "Yin Z."xsd:string |
| http://purl.uniprot.org/citations/33243860 | http://purl.uniprot.org/core/author | "Chen F.X."xsd:string |
| http://purl.uniprot.org/citations/33243860 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33243860 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/33243860 | http://purl.uniprot.org/core/pages | "eabb5872"xsd:string |
| http://purl.uniprot.org/citations/33243860 | http://purl.uniprot.org/core/title | "Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase."xsd:string |
| http://purl.uniprot.org/citations/33243860 | http://purl.uniprot.org/core/volume | "370"xsd:string |
| http://purl.uniprot.org/citations/33243860 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33243860 |
| http://purl.uniprot.org/citations/33243860 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33243860 |