| http://purl.uniprot.org/citations/33253282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33253282 | http://www.w3.org/2000/01/rdf-schema#comment | "Although venous invasion (VI) is a poor prognostic factor for patients with pancreatobiliary tract cancers, its histopathologic characteristics have not been well described. We evaluated the patterns of VI and the added benefit provided by CD31, desmin, and dual CD31‒desmin immunolabeling for identification of VI. We included 120 surgically resected pancreatobiliary tract cancer cases-59 cases as a test set with known VI and 61 cases as a validation set without information of VI. VI was classified into three patterns: intraepithelial neoplasia-like (IN-like), conventional, and destructive. Hematoxylin and eosin (H&E) staining and CD31, desmin, and dual CD31‒desmin immunolabeling were performed. Foci number and patterns of VI were compared with the test and validation sets. More foci of VI were detected by single CD31 (P = 0.022) than H&E staining in the test set. CD31 immunolabeling detected more foci of the conventional pattern of VI, and desmin immunolabeling detected more foci of the destructive pattern (all, P < 0.001). Dual CD31‒desmin immunolabeling identified more foci of VI (P = 0.012) and specifically detected more foci of IN-like (P = 0.045) and destructive patterns (P < 0.001) than H&E staining in the validation set. However, dual CD31‒desmin immunolabeling was not helpful for detecting the conventional pattern of VI in the validation set. Patients with VI detected by dual CD31‒desmin immunolabeling had shorter disease-free survival (P <0.001) than those without VI. VI detected by dual CD31‒desmin immunolabeling was a worse prognostic indicator (P = 0.009). More foci of VI could be detected with additional single CD31 or dual CD31‒desmin immunolabeling. The precise evaluation of VI with dual CD31‒desmin immunolabeling can provide additional prognostic information for patients with surgically resected pancreatobiliary tract cancers."xsd:string |
| http://purl.uniprot.org/citations/33253282 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0242571"xsd:string |
| http://purl.uniprot.org/citations/33253282 | http://purl.uniprot.org/core/author | "Shin J."xsd:string |
| http://purl.uniprot.org/citations/33253282 | http://purl.uniprot.org/core/author | "Wood L.D."xsd:string |
| http://purl.uniprot.org/citations/33253282 | http://purl.uniprot.org/core/author | "Hong S.M."xsd:string |
| http://purl.uniprot.org/citations/33253282 | http://purl.uniprot.org/core/author | "Hruban R.H."xsd:string |
| http://purl.uniprot.org/citations/33253282 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33253282 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/33253282 | http://purl.uniprot.org/core/pages | "e0242571"xsd:string |
| http://purl.uniprot.org/citations/33253282 | http://purl.uniprot.org/core/title | "Desmin and CD31 immunolabeling for detecting venous invasion of the pancreatobiliary tract cancers."xsd:string |
| http://purl.uniprot.org/citations/33253282 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/33253282 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33253282 |
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