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| http://purl.uniprot.org/citations/33268667 | http://www.w3.org/2000/01/rdf-schema#comment | "Testis-brain RNA-binding protein (TB-RBP/Translin) is known to contribute to the translational repression of a subset of haploid cell-specific mRNAs, including protamine 2 (Prm2) mRNA. Mutant mice lacking TB-RBP display abnormal spermatogenesis, despite normal male fertility. In this study, we carried out functional analysis of TB-RBP in mammalian cultured cells to understand the mechanism of translational repression by this RNA-binding protein. Although the amino acid sequence contained a eukaryotic translation initiation factor 4E (EIF4E)-recognition motif, TB-RBP failed to interact with EIF4E. In cultured cells, TB-RBP was unable to reduce the activity of luciferase encoded by a reporter mRNA carrying the 3'-untranslated region of Prm2. However, λΝ-BoxB tethering assay revealed that the complex of TB-RBP with its binding partner, Translin-associated factor X (TRAX), exhibits the ability to reduce the luciferase reporter activity by degrading the mRNA. These results suggest that TB-RBP may play a regulatory role in determining the sequence specificity of TRAX-catalyzed mRNA degradation."xsd:string |
| http://purl.uniprot.org/citations/33268667 | http://purl.org/dc/terms/identifier | "doi:10.1262/jrd.2020-120"xsd:string |
| http://purl.uniprot.org/citations/33268667 | http://purl.uniprot.org/core/author | "Baba T."xsd:string |
| http://purl.uniprot.org/citations/33268667 | http://purl.uniprot.org/core/author | "Oyama K."xsd:string |
| http://purl.uniprot.org/citations/33268667 | http://purl.uniprot.org/core/author | "Kashiwabara S.I."xsd:string |
| http://purl.uniprot.org/citations/33268667 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33268667 | http://purl.uniprot.org/core/name | "J Reprod Dev"xsd:string |
| http://purl.uniprot.org/citations/33268667 | http://purl.uniprot.org/core/pages | "35-42"xsd:string |
| http://purl.uniprot.org/citations/33268667 | http://purl.uniprot.org/core/title | "Functional characterization of testis-brain RNA-binding protein, TB-RBP/Translin, in translational regulation."xsd:string |
| http://purl.uniprot.org/citations/33268667 | http://purl.uniprot.org/core/volume | "67"xsd:string |
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