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| http://purl.uniprot.org/citations/33273122 | http://www.w3.org/2000/01/rdf-schema#comment | "α-Synuclein is expressed at high levels at presynaptic terminals, but defining its role in the regulation of neurotransmission under physiologically relevant conditions has proven elusive. We report that, in vivo, α-synuclein is responsible for the facilitation of dopamine release triggered by action potential bursts separated by short intervals (seconds) and a depression of release with longer intervals between bursts (minutes). These forms of presynaptic plasticity appear to be independent of the presence of β- and γ-synucleins or effects on presynaptic calcium and are consistent with a role for synucleins in the enhancement of synaptic vesicle fusion and turnover. These results indicate that the presynaptic effects of α-synuclein depend on specific patterns of neuronal activity."xsd:string |
| http://purl.uniprot.org/citations/33273122 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2013652117"xsd:string |
| http://purl.uniprot.org/citations/33273122 | http://purl.uniprot.org/core/author | "Choi S.J."xsd:string |
| http://purl.uniprot.org/citations/33273122 | http://purl.uniprot.org/core/author | "Edwards R.H."xsd:string |
| http://purl.uniprot.org/citations/33273122 | http://purl.uniprot.org/core/author | "Sulzer D."xsd:string |
| http://purl.uniprot.org/citations/33273122 | http://purl.uniprot.org/core/author | "Cataldi S."xsd:string |
| http://purl.uniprot.org/citations/33273122 | http://purl.uniprot.org/core/author | "Mosharov E.V."xsd:string |
| http://purl.uniprot.org/citations/33273122 | http://purl.uniprot.org/core/author | "Somayaji M."xsd:string |
| http://purl.uniprot.org/citations/33273122 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33273122 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/33273122 | http://purl.uniprot.org/core/pages | "32701-32710"xsd:string |
| http://purl.uniprot.org/citations/33273122 | http://purl.uniprot.org/core/title | "A dual role for alpha-synuclein in facilitation and depression of dopamine release from substantia nigra neurons in vivo."xsd:string |
| http://purl.uniprot.org/citations/33273122 | http://purl.uniprot.org/core/volume | "117"xsd:string |
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