| http://purl.uniprot.org/citations/33273545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33273545 | http://www.w3.org/2000/01/rdf-schema#comment | "Inactivation of Ataxia-telangiectasia mutated (ATM) gene results in an increased risk to develop cancer. We show that ATM deficiency in diffuse large B-cell lymphoma (DLBCL) significantly induce mitochondrial deacetylase sirtuin-3 (SIRT3) activity, disrupted mitochondrial structure, decreased mitochondrial respiration, and compromised TCA flux compared with DLBCL cells expressing wild type (WT)-ATM. This corresponded to enrichment of glutamate receptor and glutamine pathways in ATM deficient background compared to WT-ATM DLBCL cells. ATM-/- DLBCL cells have decreased apoptosis in contrast to radiosensitive non-cancerous A-T cells. In vivo studies using gain and loss of SIRT3 expression showed that SIRT3 promotes growth of ATM CRISPR knockout DLBCL xenografts compared to wild-type ATM control xenografts. Importantly, screening of DLBCL patient samples identified SIRT3 as a putative therapeutic target, and validated an inverse relationship between ATM and SIRT3 expression. Our data predicts SIRT3 as an important therapeutic target for DLBCL patients with ATM null phenotype."xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-020-78193-6"xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/author | "Singh M."xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/author | "Creasy H.H."xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/author | "Bhat S."xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/author | "Mayer D."xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/author | "McCracken C."xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/author | "Bhalla K."xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/author | "Gartenhaus R.B."xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/author | "Jaber S."xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/author | "Kingsbury T."xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/author | "Polster B."xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/author | "Reagan K."xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/author | "Underwood K.F."xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/author | "Lapidus R.G."xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/author | "Bhandary B."xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/author | "Nanaji N.M."xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/author | "Hamburg A."xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/author | "Hisa R."xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/author | "Jhajharia A."xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/pages | "21159"xsd:string |
| http://purl.uniprot.org/citations/33273545 | http://purl.uniprot.org/core/title | "SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma."xsd:string |