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| http://purl.uniprot.org/citations/33278342 | http://www.w3.org/2000/01/rdf-schema#comment | "Nausea, the unpleasant sensation of visceral malaise, remains a mysterious process. The area postrema is implicated in some nausea responses and is anatomically privileged to detect blood-borne signals. To investigate nausea mechanisms, we built an area postrema cell atlas through single-nucleus RNA sequencing, revealing a few neuron types. Using mouse genetic tools for cell-specific manipulation, we discovered excitatory neurons that induce nausea-related behaviors, with one neuron type mediating aversion imposed by multiple poisons. Nausea-associated responses to agonists of identified area postrema receptors were observed and suppressed by targeted cell ablation and/or gene knockout. Anatomical mapping revealed a distributed network of long-range excitatory but not inhibitory projections with subtype-specific patterning. These studies reveal the basic organization of area postrema nausea circuitry and provide a framework toward understanding and therapeutically controlling nausea."xsd:string |
| http://purl.uniprot.org/citations/33278342 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2020.11.010"xsd:string |
| http://purl.uniprot.org/citations/33278342 | http://purl.uniprot.org/core/author | "Cai Z."xsd:string |
| http://purl.uniprot.org/citations/33278342 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/33278342 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/33278342 | http://purl.uniprot.org/core/author | "Kaye J.A."xsd:string |
| http://purl.uniprot.org/citations/33278342 | http://purl.uniprot.org/core/author | "Liberles S.D."xsd:string |
| http://purl.uniprot.org/citations/33278342 | http://purl.uniprot.org/core/author | "Prescott S.L."xsd:string |
| http://purl.uniprot.org/citations/33278342 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33278342 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/33278342 | http://purl.uniprot.org/core/pages | "461-472.e5"xsd:string |
| http://purl.uniprot.org/citations/33278342 | http://purl.uniprot.org/core/title | "Area Postrema Cell Types that Mediate Nausea-Associated Behaviors."xsd:string |
| http://purl.uniprot.org/citations/33278342 | http://purl.uniprot.org/core/volume | "109"xsd:string |
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