| http://purl.uniprot.org/citations/33278357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33278357 | http://www.w3.org/2000/01/rdf-schema#comment | "COVID-19 is characterized by excessive production of pro-inflammatory cytokines and acute lung damage associated with patient mortality. While multiple inflammatory cytokines are produced by innate immune cells during SARS-CoV-2 infection, we found that only the combination of TNF-α and IFN-γ induced inflammatory cell death characterized by inflammatory cell death, PANoptosis. Mechanistically, TNF-α and IFN-γ co-treatment activated the JAK/STAT1/IRF1 axis, inducing nitric oxide production and driving caspase-8/FADD-mediated PANoptosis. TNF-α and IFN-γ caused a lethal cytokine shock in mice that mirrors the tissue damage and inflammation of COVID-19, and inhibiting PANoptosis protected mice from this pathology and death. Furthermore, treating with neutralizing antibodies against TNF-α and IFN-γ protected mice from mortality during SARS-CoV-2 infection, sepsis, hemophagocytic lymphohistiocytosis, and cytokine shock. Collectively, our findings suggest that blocking the cytokine-mediated inflammatory cell death signaling pathway identified here may benefit patients with COVID-19 or other infectious and autoinflammatory diseases by limiting tissue damage/inflammation."xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2020.11.025"xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://purl.uniprot.org/core/author | "Zheng M."xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://purl.uniprot.org/core/author | "Kanneganti T.D."xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://purl.uniprot.org/core/author | "Neale G."xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://purl.uniprot.org/core/author | "Vogel P."xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://purl.uniprot.org/core/author | "Schreiner P."xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://purl.uniprot.org/core/author | "Jonsson C.B."xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://purl.uniprot.org/core/author | "Karki R."xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://purl.uniprot.org/core/author | "Malireddi R.K.S."xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://purl.uniprot.org/core/author | "Samir P."xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://purl.uniprot.org/core/author | "Sharma B.R."xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://purl.uniprot.org/core/author | "Zalduondo L."xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://purl.uniprot.org/core/author | "Banoth B."xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://purl.uniprot.org/core/author | "Tuladhar S."xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://purl.uniprot.org/core/author | "Williams E.P."xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://purl.uniprot.org/core/author | "Webby R."xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://purl.uniprot.org/core/author | "Sundaram B."xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33278357 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://purl.uniprot.org/core/pages | "149-168.e17"xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://purl.uniprot.org/core/title | "Synergism of TNF-alpha and IFN-gamma Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes."xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://purl.uniprot.org/core/volume | "184"xsd:string |
| http://purl.uniprot.org/citations/33278357 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33278357 |