| http://purl.uniprot.org/citations/33293111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33293111 | http://www.w3.org/2000/01/rdf-schema#comment | "In vivo micro-imaging of mice is useful in studying the genetic basis of cardiac development in mutant embryos. We examined Phox2b-/- mutant mice, which lack autonomic innervation to the heart and die in utero, and investigated whether this lack of innervation causes cardiac dysfunction during embryogenesis. A VisualSonics Vevo 2100 ultrahigh-frequency linear array ultrasound machine with 30- and 40-MHz probes was used to analyze embryo size, gross characteristics, ventricular contractility and rhythm. Phox2b-/- mutant embryos underwent cessation of heartbeat and death at a greater rate than wild-type controls. We did not observe a hydrops phenotype or congenital heart defects in Phox2b-/- mutants. Analysis of heart rhythm revealed no significant correlation with genotype. Absent these signs of a progressive pathology, we suggest that Phox2b-/- mutant embryos likely die of sudden death secondary to acute arrhythmia. These data provide insight into the role of cardiac autonomic innervation during development."xsd:string |
| http://purl.uniprot.org/citations/33293111 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ultrasmedbio.2020.11.008"xsd:string |
| http://purl.uniprot.org/citations/33293111 | http://purl.uniprot.org/core/author | "Nam J."xsd:string |
| http://purl.uniprot.org/citations/33293111 | http://purl.uniprot.org/core/author | "Leatherbury L."xsd:string |
| http://purl.uniprot.org/citations/33293111 | http://purl.uniprot.org/core/author | "Mukouyama Y.S."xsd:string |
| http://purl.uniprot.org/citations/33293111 | http://purl.uniprot.org/core/author | "Kowalski W."xsd:string |
| http://purl.uniprot.org/citations/33293111 | http://purl.uniprot.org/core/author | "Garcia-Pak I."xsd:string |
| http://purl.uniprot.org/citations/33293111 | http://purl.uniprot.org/core/author | "Klaunberg B."xsd:string |
| http://purl.uniprot.org/citations/33293111 | http://purl.uniprot.org/core/author | "Mokshagundam D."xsd:string |
| http://purl.uniprot.org/citations/33293111 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33293111 | http://purl.uniprot.org/core/name | "Ultrasound Med Biol"xsd:string |
| http://purl.uniprot.org/citations/33293111 | http://purl.uniprot.org/core/pages | "751-758"xsd:string |
| http://purl.uniprot.org/citations/33293111 | http://purl.uniprot.org/core/title | "Ultrahigh-Frequency Echocardiography of Autonomic Devoid Phox2B Homozygous Embryos Does Not Reveal a Significant Cardiac Phenotype before Embryo Death."xsd:string |
| http://purl.uniprot.org/citations/33293111 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/33293111 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33293111 |
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