| http://purl.uniprot.org/citations/33293516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33293516 | http://www.w3.org/2000/01/rdf-schema#comment | "Immunosuppressive tumor microenvironment (TME) and ascites-derived spheroids in ovarian cancer (OC) facilitate tumor growth and progression, and also pose major obstacles for cancer therapy. The molecular pathways involved in the OC-TME interactions, how the crosstalk impinges on OC aggression and chemoresistance are not well-characterized. Here, we demonstrate that tumor-derived UBR5, an E3 ligase overexpressed in human OC associated with poor prognosis, is essential for OC progression principally by promoting tumor-associated macrophage recruitment and activation via key chemokines and cytokines. UBR5 is also required to sustain cell-intrinsic β-catenin-mediated signaling to promote cellular adhesion/colonization and organoid formation by controlling the p53 protein level. OC-specific targeting of UBR5 strongly augments the survival benefit of conventional chemotherapy and immunotherapies. This work provides mechanistic insights into the novel oncogene-like functions of UBR5 in regulating the OC-TME crosstalk and suggests that UBR5 is a potential therapeutic target in OC treatment for modulating the TME and cancer stemness."xsd:string |
| http://purl.uniprot.org/citations/33293516 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-20140-0"xsd:string |
| http://purl.uniprot.org/citations/33293516 | http://purl.uniprot.org/core/author | "Dong X."xsd:string |
| http://purl.uniprot.org/citations/33293516 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/33293516 | http://purl.uniprot.org/core/author | "Ma X."xsd:string |
| http://purl.uniprot.org/citations/33293516 | http://purl.uniprot.org/core/author | "Yu Z."xsd:string |
| http://purl.uniprot.org/citations/33293516 | http://purl.uniprot.org/core/author | "Shen H."xsd:string |
| http://purl.uniprot.org/citations/33293516 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
| http://purl.uniprot.org/citations/33293516 | http://purl.uniprot.org/core/author | "Zhu L."xsd:string |
| http://purl.uniprot.org/citations/33293516 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/33293516 | http://purl.uniprot.org/core/author | "Song M."xsd:string |
| http://purl.uniprot.org/citations/33293516 | http://purl.uniprot.org/core/author | "Nixon B."xsd:string |
| http://purl.uniprot.org/citations/33293516 | http://purl.uniprot.org/core/author | "Brentjens R.J."xsd:string |
| http://purl.uniprot.org/citations/33293516 | http://purl.uniprot.org/core/author | "Mai J."xsd:string |
| http://purl.uniprot.org/citations/33293516 | http://purl.uniprot.org/core/author | "Rafiq S."xsd:string |
| http://purl.uniprot.org/citations/33293516 | http://purl.uniprot.org/core/author | "Purdon T."xsd:string |
| http://purl.uniprot.org/citations/33293516 | http://purl.uniprot.org/core/author | "Yeku O.O."xsd:string |
| http://purl.uniprot.org/citations/33293516 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33293516 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/33293516 | http://purl.uniprot.org/core/pages | "6298"xsd:string |
| http://purl.uniprot.org/citations/33293516 | http://purl.uniprot.org/core/title | "Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages."xsd:string |
| http://purl.uniprot.org/citations/33293516 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/33293516 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33293516 |
| http://purl.uniprot.org/citations/33293516 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33293516 |