| http://purl.uniprot.org/citations/33293550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33293550 | http://www.w3.org/2000/01/rdf-schema#comment | "The central melanocortin system plays a fundamental role in the control of feeding and body weight. Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) also regulate overall glucose homeostasis via insulin-dependent and -independent pathways. Here, we report that a subset of ARC POMC neurons innervate the liver via preganglionic parasympathetic acetylcholine (ACh) neurons in the dorsal motor nucleus of the vagus (DMV). Optogenetic stimulation of this liver-projecting melanocortinergic pathway elevates blood glucose levels that is associated with increased expression of hepatic gluconeogenic enzymes in female and male mice. Pharmacological blockade and knockdown of the melanocortin-4 receptor gene in the DMV abolish this stimulation-induced effect. Activation of melanocortin-4 receptors inhibits DMV cholinergic neurons and optogenetic inhibition of liver-projecting parasympathetic cholinergic fibers increases blood glucose levels. This elevated blood glucose is not due to altered pancreatic hormone release. Interestingly, insulin-induced hypoglycemia increases ARC POMC neuron activity. Hence, this liver-projecting melanocortinergic circuit that we identified may play a critical role in the counterregulatory response to hypoglycemia."xsd:string |
| http://purl.uniprot.org/citations/33293550 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-020-20160-w"xsd:string |
| http://purl.uniprot.org/citations/33293550 | http://purl.uniprot.org/core/author | "Schwartz G.J."xsd:string |
| http://purl.uniprot.org/citations/33293550 | http://purl.uniprot.org/core/author | "Liu S.M."xsd:string |
| http://purl.uniprot.org/citations/33293550 | http://purl.uniprot.org/core/author | "Kwon E."xsd:string |
| http://purl.uniprot.org/citations/33293550 | http://purl.uniprot.org/core/author | "Chua S.C. Jr."xsd:string |
| http://purl.uniprot.org/citations/33293550 | http://purl.uniprot.org/core/author | "Jo Y.H."xsd:string |
| http://purl.uniprot.org/citations/33293550 | http://purl.uniprot.org/core/author | "Joung H.Y."xsd:string |
| http://purl.uniprot.org/citations/33293550 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33293550 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/33293550 | http://purl.uniprot.org/core/pages | "6295"xsd:string |
| http://purl.uniprot.org/citations/33293550 | http://purl.uniprot.org/core/title | "Optogenetic stimulation of the liver-projecting melanocortinergic pathway promotes hepatic glucose production."xsd:string |
| http://purl.uniprot.org/citations/33293550 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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