| http://purl.uniprot.org/citations/33293695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33293695 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs (miRs) are small non-coding RNAs that can have large impacts on oncogenic pathways. Possible functions of dysregulated miRs have not been studied in neurofibromatosis type 1 (NF1) plexiform neurofibromas (PNFs). In PNFs, Schwann cells (SCs) have biallelic NF1 mutations necessary for tumorigenesis. We analyzed a miR microarray comparing with normal and PNF SCs and identified differences in miR expression, and we validated in mouse PNFs versus normal mouse SCs by qRT-PCR. Among these, miR-155 was a top overexpressed miR, and its expression was regulated by RAS/MAPK signaling. Overexpression of miR-155 increased mature Nf1-/- mouse SC proliferation. In SC precursors, which model tumor-initiating cells, pharmacological and genetic inhibition of miR-155 decreased PNF-derived sphere numbers in vitro, and we identified Maf as a miR-155 target. In vivo, global deletion of miR-155 significantly decreased tumor number and volume, increasing mouse survival. Fluorescent nanoparticles entered PNFs, suggesting that an anti-miR might have therapeutic potential. However, treatment of established PNFs using anti-miR-155 peptide nucleic acid-loaded nanoparticles marginally decreased tumor numbers and did not reduce tumor growth. These results suggest that miR-155 plays a functional role in PNF growth and/or SC proliferation, and that targeting neurofibroma miRs is feasible, and might provide novel therapeutic opportunities."xsd:string |
| http://purl.uniprot.org/citations/33293695 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41388-020-01581-9"xsd:string |
| http://purl.uniprot.org/citations/33293695 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/33293695 | http://purl.uniprot.org/core/author | "Subramanian S."xsd:string |
| http://purl.uniprot.org/citations/33293695 | http://purl.uniprot.org/core/author | "Hu L."xsd:string |
| http://purl.uniprot.org/citations/33293695 | http://purl.uniprot.org/core/author | "Miller A."xsd:string |
| http://purl.uniprot.org/citations/33293695 | http://purl.uniprot.org/core/author | "Hall A."xsd:string |
| http://purl.uniprot.org/citations/33293695 | http://purl.uniprot.org/core/author | "Rose J."xsd:string |
| http://purl.uniprot.org/citations/33293695 | http://purl.uniprot.org/core/author | "Na Y."xsd:string |
| http://purl.uniprot.org/citations/33293695 | http://purl.uniprot.org/core/author | "Choi K."xsd:string |
| http://purl.uniprot.org/citations/33293695 | http://purl.uniprot.org/core/author | "Kim M.O."xsd:string |
| http://purl.uniprot.org/citations/33293695 | http://purl.uniprot.org/core/author | "Hennigan R.F."xsd:string |
| http://purl.uniprot.org/citations/33293695 | http://purl.uniprot.org/core/author | "Ratner N."xsd:string |
| http://purl.uniprot.org/citations/33293695 | http://purl.uniprot.org/core/author | "Dombi E."xsd:string |
| http://purl.uniprot.org/citations/33293695 | http://purl.uniprot.org/core/author | "Coover R.A."xsd:string |
| http://purl.uniprot.org/citations/33293695 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33293695 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/33293695 | http://purl.uniprot.org/core/pages | "951-963"xsd:string |
| http://purl.uniprot.org/citations/33293695 | http://purl.uniprot.org/core/title | "MicroRNA-155 contributes to plexiform neurofibroma growth downstream of MEK."xsd:string |
| http://purl.uniprot.org/citations/33293695 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/33293695 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33293695 |
| http://purl.uniprot.org/citations/33293695 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33293695 |
| http://purl.uniprot.org/uniprot/#_Q14180-mappedCitation-33293695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33293695 |
| http://purl.uniprot.org/uniprot/#_A0A1J0F955-mappedCitation-33293695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33293695 |