| http://purl.uniprot.org/citations/33305734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33305734 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytoplasmic accumulation of TDP-43 in motor neurons is the most prominent pathological feature in amyotrophic lateral sclerosis (ALS). A feedback cycle between nucleocytoplasmic transport (NCT) defect and TDP-43 aggregation was shown to contribute to accumulation of TDP-43 in the cytoplasm. However, little is known about cellular factors that can control the activity of NCT, thereby affecting TDP-43 accumulation in the cytoplasm. Here, we identified via FRAP and optogenetics cytosolic calcium as a key cellular factor controlling NCT of TDP-43. Dynamic and reversible changes in TDP-43 localization were observed in Drosophila sensory neurons during development. Genetic and immunohistochemical analyses identified the cytosolic calcium-Calpain-A-Importin α3 pathway as a regulatory mechanism underlying NCT of TDP-43. In C9orf72 ALS fly models, upregulation of the pathway activity by increasing cytosolic calcium reduced cytoplasmic accumulation of TDP-43 and mitigated behavioral defects. Together, these results suggest the calcium-Calpain-A-Importin α3 pathway as a potential therapeutic target of ALS."xsd:string |
| http://purl.uniprot.org/citations/33305734 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.60132"xsd:string |
| http://purl.uniprot.org/citations/33305734 | http://purl.uniprot.org/core/author | "Lee S.B."xsd:string |
| http://purl.uniprot.org/citations/33305734 | http://purl.uniprot.org/core/author | "Kim H.J."xsd:string |
| http://purl.uniprot.org/citations/33305734 | http://purl.uniprot.org/core/author | "Lee D."xsd:string |
| http://purl.uniprot.org/citations/33305734 | http://purl.uniprot.org/core/author | "Park J.H."xsd:string |
| http://purl.uniprot.org/citations/33305734 | http://purl.uniprot.org/core/author | "Kim E.S."xsd:string |
| http://purl.uniprot.org/citations/33305734 | http://purl.uniprot.org/core/author | "Cho J.H."xsd:string |
| http://purl.uniprot.org/citations/33305734 | http://purl.uniprot.org/core/author | "Hwang D."xsd:string |
| http://purl.uniprot.org/citations/33305734 | http://purl.uniprot.org/core/author | "Park S.S."xsd:string |
| http://purl.uniprot.org/citations/33305734 | http://purl.uniprot.org/core/author | "Kim K.M."xsd:string |
| http://purl.uniprot.org/citations/33305734 | http://purl.uniprot.org/core/author | "Jeong Y."xsd:string |
| http://purl.uniprot.org/citations/33305734 | http://purl.uniprot.org/core/author | "Shen C.J."xsd:string |
| http://purl.uniprot.org/citations/33305734 | http://purl.uniprot.org/core/author | "Jeon Y.M."xsd:string |
| http://purl.uniprot.org/citations/33305734 | http://purl.uniprot.org/core/author | "Chung C.G."xsd:string |
| http://purl.uniprot.org/citations/33305734 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33305734 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/33305734 | http://purl.uniprot.org/core/pages | "e60132"xsd:string |
| http://purl.uniprot.org/citations/33305734 | http://purl.uniprot.org/core/title | "Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin alpha3."xsd:string |
| http://purl.uniprot.org/citations/33305734 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/33305734 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33305734 |
| http://purl.uniprot.org/citations/33305734 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33305734 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFT3-mappedCitation-33305734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33305734 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHH8-mappedCitation-33305734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33305734 |