| http://purl.uniprot.org/citations/33310185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33310185 | http://www.w3.org/2000/01/rdf-schema#comment | "Abnormal crosstalk between gut immune and the liver was involved in nonalcoholic steatohepatitis (NASH). Mice with methionine choline-deficient (MCD) diet-induced NASH presented an imbalance of pro-(IL-6 and IFN-γ) and anti-inflammatory cytokines (IL-10) in the intestine. We also clarified that the ratio of CD4+ T cells and found that the NASH mesenteric lymph node (MLN) presents decreased numbers of CD4+Th17 cells but increased numbers of CD4+CD8+FoxP3+ regulatory T cells (Tregs). Furthermore, the intestinal immune imbalance in NASH was attributed to impaired gut chemokine receptor 9 (CCR9)/chemokine ligand 25 (CCL25) signalling, which is a crucial pathway for immune cell homing in the gut. We also demonstrated that CD4+CCR9+ T cell homing was dependent on CCL25 and that the numbers and migration abilities of CD4+CCR9+ T cells were reduced in NASH. Interestingly, the analysis of dendritic cell (DC) subsets showed that the numbers and retinal dehydrogenase (RALDH) activity of CD103+CD11b+ DCs were decreased and that the ability of these cells to upregulate CD4+ T cell CCR9 expression was damaged in NASH. Taken together, impaired intestinal CCR9/CCL25 signalling induced by CD103+CD11b+ DC dysfunction contributes to the gut immune imbalance observed in NASH."xsd:string |
| http://purl.uniprot.org/citations/33310185 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2020.12.007"xsd:string |
| http://purl.uniprot.org/citations/33310185 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/33310185 | http://purl.uniprot.org/core/author | "Gao W."xsd:string |
| http://purl.uniprot.org/citations/33310185 | http://purl.uniprot.org/core/author | "Li N."xsd:string |
| http://purl.uniprot.org/citations/33310185 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/33310185 | http://purl.uniprot.org/core/author | "Tang H."xsd:string |
| http://purl.uniprot.org/citations/33310185 | http://purl.uniprot.org/core/author | "Wang Y.'"xsd:string |
| http://purl.uniprot.org/citations/33310185 | http://purl.uniprot.org/core/author | "Bi J."xsd:string |
| http://purl.uniprot.org/citations/33310185 | http://purl.uniprot.org/core/author | "Mao J."xsd:string |
| http://purl.uniprot.org/citations/33310185 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33310185 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/33310185 | http://purl.uniprot.org/core/pages | "34-40"xsd:string |
| http://purl.uniprot.org/citations/33310185 | http://purl.uniprot.org/core/title | "Impaired CCR9/CCL25 signalling induced by inefficient dendritic cells contributes to intestinal immune imbalance in nonalcoholic steatohepatitis."xsd:string |
| http://purl.uniprot.org/citations/33310185 | http://purl.uniprot.org/core/volume | "534"xsd:string |
| http://purl.uniprot.org/citations/33310185 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33310185 |
| http://purl.uniprot.org/citations/33310185 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33310185 |
| http://purl.uniprot.org/uniprot/#_D3YWJ1-mappedCitation-33310185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33310185 |
| http://purl.uniprot.org/uniprot/#_O35903-mappedCitation-33310185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33310185 |
| http://purl.uniprot.org/uniprot/#_Q3V2F3-mappedCitation-33310185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33310185 |
| http://purl.uniprot.org/uniprot/#_Q3V144-mappedCitation-33310185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33310185 |
| http://purl.uniprot.org/uniprot/#_Q3U4J3-mappedCitation-33310185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33310185 |
| http://purl.uniprot.org/uniprot/#_Q8C938-mappedCitation-33310185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33310185 |
| http://purl.uniprot.org/uniprot/#_Q9WUT7-mappedCitation-33310185 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33310185 |