| http://purl.uniprot.org/citations/33315855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33315855 | http://www.w3.org/2000/01/rdf-schema#comment | "Stem-cell niche signaling is short-range in nature, such that only stem cells but not their differentiating progeny receive self-renewing signals. At the apical tip of the Drosophila testis, 8 to 10 germline stem cells (GSCs) surround the hub, a cluster of somatic cells that organize the stem-cell niche. We have previously shown that GSCs form microtubule-based nanotubes (MT-nanotubes) that project into the hub cells, serving as the platform for niche signal reception; this spatial arrangement ensures the reception of the niche signal specifically by stem cells but not by differentiating cells. The receptor Thickveins (Tkv) is expressed by GSCs and localizes to the surface of MT-nanotubes, where it receives the hub-derived ligand Decapentaplegic (Dpp). The fate of Tkv receptor after engaging in signaling on the MT-nanotubes has been unclear. Here we demonstrate that the Tkv receptor is internalized into hub cells from the MT-nanotube surface and subsequently degraded in the hub cell lysosomes. Perturbation of MT-nanotube formation and Tkv internalization from MT-nanotubes into hub cells both resulted in an overabundance of Tkv protein in GSCs and hyperactivation of a downstream signal, suggesting that the MT-nanotubes also serve a second purpose to dampen the niche signaling. Together, our results demonstrate that MT-nanotubes play dual roles to ensure the short-range nature of niche signaling by (1) providing an exclusive interface for the niche ligand-receptor interaction; and (2) limiting the amount of stem cell receptors available for niche signal reception."xsd:string |
| http://purl.uniprot.org/citations/33315855 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.3001003"xsd:string |
| http://purl.uniprot.org/citations/33315855 | http://purl.uniprot.org/core/author | "Simao T."xsd:string |
| http://purl.uniprot.org/citations/33315855 | http://purl.uniprot.org/core/author | "Inaba M."xsd:string |
| http://purl.uniprot.org/citations/33315855 | http://purl.uniprot.org/core/author | "Antel M."xsd:string |
| http://purl.uniprot.org/citations/33315855 | http://purl.uniprot.org/core/author | "Cowan A.E."xsd:string |
| http://purl.uniprot.org/citations/33315855 | http://purl.uniprot.org/core/author | "Gasek N."xsd:string |
| http://purl.uniprot.org/citations/33315855 | http://purl.uniprot.org/core/author | "Ladyzhets S."xsd:string |
| http://purl.uniprot.org/citations/33315855 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33315855 | http://purl.uniprot.org/core/name | "PLoS Biol"xsd:string |
| http://purl.uniprot.org/citations/33315855 | http://purl.uniprot.org/core/pages | "e3001003"xsd:string |
| http://purl.uniprot.org/citations/33315855 | http://purl.uniprot.org/core/title | "Self-limiting stem-cell niche signaling through degradation of a stem-cell receptor."xsd:string |
| http://purl.uniprot.org/citations/33315855 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/33315855 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33315855 |
| http://purl.uniprot.org/citations/33315855 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33315855 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGY5-mappedCitation-33315855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33315855 |
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| http://purl.uniprot.org/uniprot/#_P42003-mappedCitation-33315855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33315855 |
| http://purl.uniprot.org/uniprot/#_M9PBX0-mappedCitation-33315855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33315855 |
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| http://purl.uniprot.org/uniprot/#_P25724-mappedCitation-33315855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33315855 |
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| http://purl.uniprot.org/uniprot/#_P06603-mappedCitation-33315855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33315855 |