| http://purl.uniprot.org/citations/33317172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33317172 | http://www.w3.org/2000/01/rdf-schema#comment | "Human endogenous retroviruses (HERVs) comprise 8% of the human genome, and HERV DNA was reported to be essential in human embryonic development. Specifically, HERV-W encodes a protein, syncytin-1, alternatively known as ERVWE1 (Human Endogenous Retrovirus W EnvC7-1 Envelope Protein), participating in human placental morphogenesis and having a role in immune system regulation. Syncytin-1 activity is increased in neuropsychiatric disorders, autoimmune diseases, and cancer. In our study, forty-four women in the third trimester of pregnancy were tested for ERVWE1 plasma levels. In concomitance with blood samples the following rating scales were administered to women: the Edinburgh Postnatal Depression Scale (EPDS), State Anxiety Inventory (STAI-S), Trait Anxiety Inventory (STAI-T), and Prenatal Attachment Inventory (PAI). We found that higher ERVWE1 protein plasma levels were significantly associated with higher PAI scores (p = 0.02), an earlier gestational age at the time of blood collection (p = 0.01), a longer duration of symptoms (p = 0.03), and fewer lifetime attempted suicides (p = 0.02). Our results seem to support the role of ERVWE1 in maintaining clinical psychiatric symptoms as a result of potential prolonged inflammation. At the same time, this protein may have a protective role in pregnant women by a reduction of suicidal behavior and a better mother-fetus relationship."xsd:string |
| http://purl.uniprot.org/citations/33317172 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijerph17249217"xsd:string |
| http://purl.uniprot.org/citations/33317172 | http://purl.uniprot.org/core/author | "Grassi S."xsd:string |
| http://purl.uniprot.org/citations/33317172 | http://purl.uniprot.org/core/author | "Bollati V."xsd:string |
| http://purl.uniprot.org/citations/33317172 | http://purl.uniprot.org/core/author | "Serati M."xsd:string |
| http://purl.uniprot.org/citations/33317172 | http://purl.uniprot.org/core/author | "Buoli M."xsd:string |
| http://purl.uniprot.org/citations/33317172 | http://purl.uniprot.org/core/author | "Barkin J.L."xsd:string |
| http://purl.uniprot.org/citations/33317172 | http://purl.uniprot.org/core/author | "Esposito C.M."xsd:string |
| http://purl.uniprot.org/citations/33317172 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33317172 | http://purl.uniprot.org/core/name | "Int J Environ Res Public Health"xsd:string |
| http://purl.uniprot.org/citations/33317172 | http://purl.uniprot.org/core/pages | "E9217"xsd:string |
| http://purl.uniprot.org/citations/33317172 | http://purl.uniprot.org/core/title | "The Association between Plasma ERVWE1 Concentrations and Affective Symptoms during Pregnancy: Is This a Friendly Alien?"xsd:string |
| http://purl.uniprot.org/citations/33317172 | http://purl.uniprot.org/core/volume | "17"xsd:string |
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