| http://purl.uniprot.org/citations/33318306 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33318306 | http://www.w3.org/2000/01/rdf-schema#comment | "Obesity is characterized by the expansion of adipose tissue which is partially modulated by adipogenesis. In the present study, we identified five differentially expressed genes by incorporating two adipogenesis-related datasets from the GEO database and their correlation with adipogenic markers. However, the role of scavenger receptor class A member 3 (SCARA3) in obesity-related disorders has been rarely reported. We found that Scara3 expression in old adipose tissue-derived mesenchymal stem cells (Ad-MSCs) was lower than it in young Ad-MSCs. Obese mice caused by deletion of the leptin receptor gene (db/db) or by a high-fat diet both showed reduced Scara3 expression in inguinal white adipose tissue. Moreover, hypermethylation of SCARA3 was observed in patients with type 2 diabetes and atherosclerosis. Data from the CTD database indicated that SCARA3 is a potential target for metabolic diseases. Mechanistically, JUN was predicted as a transcriptional factor of SCARA3 in different databases which is consistent with our further bioinformatics analysis. Collectively, our study suggested that SCARA3 is potentially associated with age-related metabolic dysfunction, which provided new insights into the pathogenesis and treatment of obesity as well as other obesity-associated metabolic complications."xsd:string |
| http://purl.uniprot.org/citations/33318306 | http://purl.org/dc/terms/identifier | "doi:10.18632/aging.202228"xsd:string |
| http://purl.uniprot.org/citations/33318306 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/33318306 | http://purl.uniprot.org/core/author | "Xiao Y."xsd:string |
| http://purl.uniprot.org/citations/33318306 | http://purl.uniprot.org/core/author | "Peng H."xsd:string |
| http://purl.uniprot.org/citations/33318306 | http://purl.uniprot.org/core/author | "Guo Q."xsd:string |
| http://purl.uniprot.org/citations/33318306 | http://purl.uniprot.org/core/author | "Su T."xsd:string |
| http://purl.uniprot.org/citations/33318306 | http://purl.uniprot.org/core/author | "Li C.J."xsd:string |
| http://purl.uniprot.org/citations/33318306 | http://purl.uniprot.org/core/author | "Luo X.H."xsd:string |
| http://purl.uniprot.org/citations/33318306 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33318306 | http://purl.uniprot.org/core/name | "Aging (Albany NY)"xsd:string |
| http://purl.uniprot.org/citations/33318306 | http://purl.uniprot.org/core/pages | "2149-2167"xsd:string |
| http://purl.uniprot.org/citations/33318306 | http://purl.uniprot.org/core/title | "Identification of SCARA3 with potential roles in metabolic disorders."xsd:string |
| http://purl.uniprot.org/citations/33318306 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/33318306 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33318306 |
| http://purl.uniprot.org/citations/33318306 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33318306 |
| http://purl.uniprot.org/uniprot/#_Q6AZY7-mappedCitation-33318306 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33318306 |
| http://purl.uniprot.org/uniprot/Q6AZY7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33318306 |