| http://purl.uniprot.org/citations/33318499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33318499 | http://www.w3.org/2000/01/rdf-schema#comment | "Olfactomedin 4 (OLFM4) is expressed in normal prostate epithelial cells and immortalized normal human prostate epithelial cells (RWPE1), but the identity of OLFM4-expressing cells within these populations and OLFM4's physiological functions in these cells have not been elucidated. Using single-cell RNA sequencing analysis, we found here that OLFM4 was expressed in multiple stem/progenitor-like cell populations in both the normal prostate epithelium and RWPE1 cells and was frequently co-expressed with KRT13 and LY6D in RWPE1 cells. Functionally, OLFM4-knockout RWPE1 cells exhibited enhanced proliferation of the stem/progenitor-like cell population, shifts stem/progenitor-like cell division to favor symmetric division and differentiated into higher levels PSA expression cells in organoid assays compared with OLFM4-wild RWPE1 cells. Bulk-cell RNA sequencing analysis pinpointed that cMYC expression were enhanced in the OLFM4-knockout RWPE1 cells compared with OLFM4-wild cells. Molecular and signaling pathway studies revealed an increase in the WNT/APC/MYC signaling pathway gene signature, as well as that of MYC target genes that regulate multiple biological processes, in OLFM4-knockout RWPE1 cells. These findings indicated that OLFM4 is co-expressed with multiple stem/progenitor cell marker genes in prostate epithelial cells and acts as a novel mediator in prostate stem/progenitor cell proliferation and differentiation."xsd:string |
| http://purl.uniprot.org/citations/33318499 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-020-78774-5"xsd:string |
| http://purl.uniprot.org/citations/33318499 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/33318499 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/33318499 | http://purl.uniprot.org/core/author | "Zhu J."xsd:string |
| http://purl.uniprot.org/citations/33318499 | http://purl.uniprot.org/core/author | "Chin K."xsd:string |
| http://purl.uniprot.org/citations/33318499 | http://purl.uniprot.org/core/author | "Rodgers G.P."xsd:string |
| http://purl.uniprot.org/citations/33318499 | http://purl.uniprot.org/core/author | "Chaitankar V."xsd:string |
| http://purl.uniprot.org/citations/33318499 | http://purl.uniprot.org/core/author | "Pirooznia M."xsd:string |
| http://purl.uniprot.org/citations/33318499 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33318499 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/33318499 | http://purl.uniprot.org/core/pages | "21924"xsd:string |
| http://purl.uniprot.org/citations/33318499 | http://purl.uniprot.org/core/title | "Olfactomedin 4 mediation of prostate stem/progenitor-like cell proliferation and differentiation via MYC."xsd:string |
| http://purl.uniprot.org/citations/33318499 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/33318499 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33318499 |
| http://purl.uniprot.org/citations/33318499 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33318499 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-33318499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33318499 |
| http://purl.uniprot.org/uniprot/#_A0N2G3-mappedCitation-33318499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33318499 |
| http://purl.uniprot.org/uniprot/#_A0A224B085-mappedCitation-33318499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33318499 |
| http://purl.uniprot.org/uniprot/#_B3CJ86-mappedCitation-33318499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33318499 |
| http://purl.uniprot.org/uniprot/#_B3CJ87-mappedCitation-33318499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33318499 |
| http://purl.uniprot.org/uniprot/#_B3CJ88-mappedCitation-33318499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33318499 |
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| http://purl.uniprot.org/uniprot/#_B3CJB3-mappedCitation-33318499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33318499 |