| http://purl.uniprot.org/citations/33318509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33318509 | http://www.w3.org/2000/01/rdf-schema#comment | "MZB1 is an endoplasmic reticulum (ER)-resident protein that plays an important role in the humoral immune response by enhancing the interaction of the μ immunoglobulin (Ig) heavy chain with the chaperone GRP94 and by augmenting the secretion of IgM. Here, we show that MZB1 is also expressed in plasmacytoid dendritic cells (pDCs). Mzb1-/- pDCs have a defect in the secretion of interferon (IFN) α upon Toll-like receptor (TLR) 9 stimulation and a reduced ability to enhance B cell differentiation towards plasma cells. Mzb1-/- pDCs do not properly expand the ER upon TLR9 stimulation, which may be accounted for by an impaired activation of ATF6, a regulator of the unfolded protein response (UPR). Pharmacological inhibition of ATF6 cleavage in stimulated wild type pDCs mimics the diminished IFNα secretion by Mzb1-/- pDCs. Thus, MZB1 enables pDCs to secrete high amounts of IFNα by mitigating ER stress via the ATF6-mediated UPR."xsd:string |
| http://purl.uniprot.org/citations/33318509 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-020-78293-3"xsd:string |
| http://purl.uniprot.org/citations/33318509 | http://purl.uniprot.org/core/author | "Corrado M."xsd:string |
| http://purl.uniprot.org/citations/33318509 | http://purl.uniprot.org/core/author | "Pearce E.L."xsd:string |
| http://purl.uniprot.org/citations/33318509 | http://purl.uniprot.org/core/author | "Grosschedl R."xsd:string |
| http://purl.uniprot.org/citations/33318509 | http://purl.uniprot.org/core/author | "Pearce E.J."xsd:string |
| http://purl.uniprot.org/citations/33318509 | http://purl.uniprot.org/core/author | "Kapoor T."xsd:string |
| http://purl.uniprot.org/citations/33318509 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33318509 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/33318509 | http://purl.uniprot.org/core/pages | "21626"xsd:string |
| http://purl.uniprot.org/citations/33318509 | http://purl.uniprot.org/core/title | "MZB1 enables efficient interferon alpha secretion in stimulated plasmacytoid dendritic cells."xsd:string |
| http://purl.uniprot.org/citations/33318509 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/33318509 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33318509 |
| http://purl.uniprot.org/citations/33318509 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33318509 |
| http://purl.uniprot.org/uniprot/#_A0A494B9S2-mappedCitation-33318509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33318509 |
| http://purl.uniprot.org/uniprot/#_Q9D8I1-mappedCitation-33318509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33318509 |
| http://purl.uniprot.org/uniprot/Q9D8I1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33318509 |
| http://purl.uniprot.org/uniprot/A0A494B9S2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/33318509 |