| http://purl.uniprot.org/citations/33319750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33319750 | http://www.w3.org/2000/01/rdf-schema#comment | "Aging is characterized by extensive metabolic reprogramming. To identify metabolic pathways associated with aging, we analyzed age-dependent changes in the metabolomes of long-lived Drosophila melanogaster. Among the metabolites that changed, levels of tyrosine were increased with age in long-lived flies. We demonstrate that the levels of enzymes in the tyrosine degradation pathway increase with age in wild-type flies. Whole-body and neuronal-specific downregulation of enzymes in the tyrosine degradation pathway significantly extends Drosophila lifespan, causes alterations of metabolites associated with increased lifespan, and upregulates the levels of tyrosine-derived neuromediators. Moreover, feeding wild-type flies with tyrosine increased their lifespan. Mechanistically, we show that suppression of ETC complex I drives the upregulation of enzymes in the tyrosine degradation pathway, an effect that can be rescued by tigecycline, an FDA-approved drug that specifically suppresses mitochondrial translation. In addition, tyrosine supplementation partially rescued lifespan of flies with ETC complex I suppression. Altogether, our study highlights the tyrosine degradation pathway as a regulator of longevity."xsd:string |
| http://purl.uniprot.org/citations/33319750 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.58053"xsd:string |
| http://purl.uniprot.org/citations/33319750 | http://purl.uniprot.org/core/author | "Asara J.M."xsd:string |
| http://purl.uniprot.org/citations/33319750 | http://purl.uniprot.org/core/author | "Perrimon N."xsd:string |
| http://purl.uniprot.org/citations/33319750 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/33319750 | http://purl.uniprot.org/core/author | "Rabinowitz J.D."xsd:string |
| http://purl.uniprot.org/citations/33319750 | http://purl.uniprot.org/core/author | "Cracan V."xsd:string |
| http://purl.uniprot.org/citations/33319750 | http://purl.uniprot.org/core/author | "Binari R."xsd:string |
| http://purl.uniprot.org/citations/33319750 | http://purl.uniprot.org/core/author | "Ramesh D."xsd:string |
| http://purl.uniprot.org/citations/33319750 | http://purl.uniprot.org/core/author | "Parkhitko A.A."xsd:string |
| http://purl.uniprot.org/citations/33319750 | http://purl.uniprot.org/core/author | "Olsen A.L."xsd:string |
| http://purl.uniprot.org/citations/33319750 | http://purl.uniprot.org/core/author | "Brockmann A."xsd:string |
| http://purl.uniprot.org/citations/33319750 | http://purl.uniprot.org/core/author | "Filine E."xsd:string |
| http://purl.uniprot.org/citations/33319750 | http://purl.uniprot.org/core/author | "Leshchiner D."xsd:string |
| http://purl.uniprot.org/citations/33319750 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33319750 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/33319750 | http://purl.uniprot.org/core/pages | "e58053"xsd:string |
| http://purl.uniprot.org/citations/33319750 | http://purl.uniprot.org/core/title | "Downregulation of the tyrosine degradation pathway extends Drosophila lifespan."xsd:string |
| http://purl.uniprot.org/citations/33319750 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/33319750 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33319750 |
| http://purl.uniprot.org/citations/33319750 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33319750 |
| http://purl.uniprot.org/uniprot/Q9VY42#attribution-3FE5923473F47BE150B6E5CB621B8658 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/33319750 |
| http://purl.uniprot.org/uniprot/#_O18683-mappedCitation-33319750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33319750 |
| http://purl.uniprot.org/uniprot/#_P41964-mappedCitation-33319750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33319750 |