Results

RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/33336728http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/33336728http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Early detection and effective evaluation are helpful for renal cancer diagnosis and treatment. NudCD1 and NF-κΒ are abnormally expressed in tumors and inflammations. However, their role in early detection and course evaluation of renal cancer has not been reported.

Patients and methods

The serum of clinically diagnosed renal cancer patients and healthy volunteers (control group) were collected to measure the expressions of NudCD1 and NF-κΒ mRNA by Real time PCR.

Results

NudCD1 and NF-κΒ mRNA in renal cancer patients were significantly upregulated compared to controls (p<0.05). NudCD1 was positively correlated with tumor diameter, TNM stage, lymph node metastasis, degree of differentiation, and distant metastasis (p<0.05); whereas, NF-κΒ was positively related to TNM stage, lymph node metastasis, and distant metastasis (p<0.05) but not to tumor diameter and differentiation degree. NudCD1 and NF-κΒ were positively correlated. The combined detection improved the diagnostic specificity and sensitivity of renal cancer.

Conclusions

The expression of NudCD1 and NF-κΒ is increased in renal cancer and is correlated with renal cancer clinicopathological characteristics. The combined detection of NudCD1 and NF-κΒ can improve the early diagnosis of kidney cancer."xsd:string
http://purl.uniprot.org/citations/33336728http://purl.org/dc/terms/identifier"doi:10.26355/eurrev_202012_23999"xsd:string
http://purl.uniprot.org/citations/33336728http://purl.uniprot.org/core/author"He Y."xsd:string
http://purl.uniprot.org/citations/33336728http://purl.uniprot.org/core/author"Wei W."xsd:string
http://purl.uniprot.org/citations/33336728http://purl.uniprot.org/core/author"Liu Y.P."xsd:string
http://purl.uniprot.org/citations/33336728http://purl.uniprot.org/core/author"Lei C.J."xsd:string
http://purl.uniprot.org/citations/33336728http://purl.uniprot.org/core/author"You C.J."xsd:string
http://purl.uniprot.org/citations/33336728http://purl.uniprot.org/core/date"2020"xsd:gYear
http://purl.uniprot.org/citations/33336728http://purl.uniprot.org/core/name"Eur Rev Med Pharmacol Sci"xsd:string
http://purl.uniprot.org/citations/33336728http://purl.uniprot.org/core/pages"12109-12115"xsd:string
http://purl.uniprot.org/citations/33336728http://purl.uniprot.org/core/title"Analysis of NudCD1 and NF-kappaBeta in the early detection and course evaluation of renal cancer."xsd:string
http://purl.uniprot.org/citations/33336728http://purl.uniprot.org/core/volume"24"xsd:string
http://purl.uniprot.org/citations/33336728http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/33336728
http://purl.uniprot.org/citations/33336728http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/33336728
http://purl.uniprot.org/uniprot/#_A0A510GAH8-mappedCitation-33336728http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/33336728
http://purl.uniprot.org/uniprot/#_P19838-mappedCitation-33336728http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/33336728
http://purl.uniprot.org/uniprot/#_Q71EB9-mappedCitation-33336728http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/33336728
http://purl.uniprot.org/uniprot/#_Q96RS6-mappedCitation-33336728http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/33336728
http://purl.uniprot.org/uniprot/Q96RS6http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/33336728
http://purl.uniprot.org/uniprot/P19838http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/33336728
http://purl.uniprot.org/uniprot/A0A510GAH8http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/33336728
http://purl.uniprot.org/uniprot/Q71EB9http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/33336728