| http://purl.uniprot.org/citations/33337568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33337568 | http://www.w3.org/2000/01/rdf-schema#comment | "Studies of neuroglial interaction largely depend on cell-specific gene knockout (KO) experiments using Cre recombinase. However, genes known as glial-specific genes have recently been reported to be expressed in neuroglial stem cells, leading to the possibility that a glia-specific Cre driver results in unwanted gene deletion in neurons, which may affect sound interpretation. 2',3'-Cyclic nucleotide 3'-phosphodiesterase (CNP) is generally considered to be an oligodendrocyte (OL) marker. Accordingly, Cnp promoter-controlled Cre recombinase has been used to create OL-specific gene targeting mice. However, in this study, using Rosa26-tdTomato-reporter/Cnp-Cre mice, we found that many forebrain neurons and cerebellar Purkinje neurons belong to the lineages of Cnp-expressing neuroglial stem cells. To answer whether gene targeting by Cnp-Cre can induce neuron-autonomous defects, we conditionally deleted an essential autophagy gene, Atg7, in Cnp-Cre mice. The Cnp-Cre-mediated Atg7 KO mice showed extensive p62 inclusion in neurons, including cerebellar Purkinje neurons with extensive neurodegeneration. Furthermore, neuronal areas showing p62 inclusion in Cnp-Cre-mediated Atg7 KO mice overlapped with the neuronal lineage of Cnp-expressing neuroglial stem cells. Moreover, Cnp-Cre-mediated Atg7-KO mice did not develop critical defects in myelination. Our results demonstrate that a large population of central neurons are derived from Cnp-expressing neuroglial stem cells; thus, conditional gene targeting using the Cnp promoter, which is known to be OL-specific, can induce neuron-autonomous phenotypes."xsd:string |
| http://purl.uniprot.org/citations/33337568 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.202001366rr"xsd:string |
| http://purl.uniprot.org/citations/33337568 | http://purl.uniprot.org/core/author | "Lee H.K."xsd:string |
| http://purl.uniprot.org/citations/33337568 | http://purl.uniprot.org/core/author | "Kim Y.H."xsd:string |
| http://purl.uniprot.org/citations/33337568 | http://purl.uniprot.org/core/author | "Lee S.J."xsd:string |
| http://purl.uniprot.org/citations/33337568 | http://purl.uniprot.org/core/author | "Kim H.R."xsd:string |
| http://purl.uniprot.org/citations/33337568 | http://purl.uniprot.org/core/author | "Lee K.E."xsd:string |
| http://purl.uniprot.org/citations/33337568 | http://purl.uniprot.org/core/author | "Jang S.Y."xsd:string |
| http://purl.uniprot.org/citations/33337568 | http://purl.uniprot.org/core/author | "Jo J."xsd:string |
| http://purl.uniprot.org/citations/33337568 | http://purl.uniprot.org/core/author | "Park D.K."xsd:string |
| http://purl.uniprot.org/citations/33337568 | http://purl.uniprot.org/core/author | "Shin Y.K."xsd:string |
| http://purl.uniprot.org/citations/33337568 | http://purl.uniprot.org/core/author | "Oh Y."xsd:string |
| http://purl.uniprot.org/citations/33337568 | http://purl.uniprot.org/core/author | "Go H."xsd:string |
| http://purl.uniprot.org/citations/33337568 | http://purl.uniprot.org/core/author | "Song M.Y."xsd:string |
| http://purl.uniprot.org/citations/33337568 | http://purl.uniprot.org/core/author | "Park H.T."xsd:string |
| http://purl.uniprot.org/citations/33337568 | http://purl.uniprot.org/core/author | "Jo Y.R."xsd:string |
| http://purl.uniprot.org/citations/33337568 | http://purl.uniprot.org/core/author | "Cheon S.M."xsd:string |
| http://purl.uniprot.org/citations/33337568 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33337568 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/33337568 | http://purl.uniprot.org/core/pages | "e21225"xsd:string |
| http://purl.uniprot.org/citations/33337568 | http://purl.uniprot.org/core/title | "Potential neuron-autonomous Purkinje cell degeneration by 2',3'-cyclic nucleotide 3'-phosphodiesterase promoter/Cre-mediated autophagy impairments."xsd:string |
| http://purl.uniprot.org/citations/33337568 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/33337568 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33337568 |
| http://purl.uniprot.org/citations/33337568 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33337568 |