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Background & aims

Defective rostrocaudal colonization of the gut by vagal neural crest cells (vNCCs) results in Hirschsprung's disease (HSCR), which is characterized by aganglionosis in variable lengths of the distal bowel. Skip segment Hirschsprung's disease (SSHD), referring to a ganglionated segment within an otherwise aganglionic intestine, contradicts HSCR pathogenesis and underscores a significant gap in our understanding of the development of the enteric nervous system. Here, we aimed to identify the embryonic origin of the ganglionic segments in SSHD.

Methods

Intestinal biopsy specimens from HSCR patients were prepared via the Swiss-roll technique to search for SSHD cases. NCC migration from the neural tube to the gut was spatiotemporally traced using targeted cell lineages and gene manipulation in mice.

Results

After invading the mesentery surrounding the foregut, vNCCs separated into 2 populations: mesenteric NCCs (mNCCs) proceeded to migrate along the mesentery, whereas enteric NCCs invaded the foregut to migrate along the gut. mNCCs not only produced neurons and glia within the gut mesentery, but also continuously complemented the enteric NCC pool. Two new cases of SSHD were identified from 183 HSCR patients, and Ednrb-mutant mice, but not Ret-/- mice, showed a high incidence rate of SSHD-like phenotypes.

Conclusions

mNCCs, a subset of vNCCs that migrate into the gut via the gut mesentery to give rise to enteric neurons, could provide an embryologic explanation for SSHD. These findings lead to novel insights into the development of the enteric nervous system and the etiology of HSCR."xsd:string
http://purl.uniprot.org/citations/33340715http://purl.org/dc/terms/identifier"doi:10.1016/j.jcmgh.2020.12.010"xsd:string
http://purl.uniprot.org/citations/33340715http://purl.uniprot.org/core/author"Chen W."xsd:string
http://purl.uniprot.org/citations/33340715http://purl.uniprot.org/core/author"Gao Z."xsd:string
http://purl.uniprot.org/citations/33340715http://purl.uniprot.org/core/author"Du M."xsd:string
http://purl.uniprot.org/citations/33340715http://purl.uniprot.org/core/author"Gu Y."xsd:string
http://purl.uniprot.org/citations/33340715http://purl.uniprot.org/core/author"Liu L."xsd:string
http://purl.uniprot.org/citations/33340715http://purl.uniprot.org/core/author"Sun Q."xsd:string
http://purl.uniprot.org/citations/33340715http://purl.uniprot.org/core/author"Zhang W."xsd:string
http://purl.uniprot.org/citations/33340715http://purl.uniprot.org/core/author"Wang L."xsd:string
http://purl.uniprot.org/citations/33340715http://purl.uniprot.org/core/author"Yu Q."xsd:string
http://purl.uniprot.org/citations/33340715http://purl.uniprot.org/core/author"Zhu K."xsd:string
http://purl.uniprot.org/citations/33340715http://purl.uniprot.org/core/author"Niu X."xsd:string
http://purl.uniprot.org/citations/33340715http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/33340715http://purl.uniprot.org/core/name"Cell Mol Gastroenterol Hepatol"xsd:string
http://purl.uniprot.org/citations/33340715http://purl.uniprot.org/core/pages"1-24"xsd:string
http://purl.uniprot.org/citations/33340715http://purl.uniprot.org/core/title"Mesenteric Neural Crest Cells Are the Embryological Basis of Skip Segment Hirschsprung's Disease."xsd:string
http://purl.uniprot.org/citations/33340715http://purl.uniprot.org/core/volume"12"xsd:string
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