DESCRIBE <http://purl.uniprot.org/citations/33349207>

Subject	Predicate	Object
http://purl.uniprot.org/citations/33349207	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/33349207	http://www.w3.org/2000/01/rdf-schema#comment	" Objectives Antibody-mediated injury in chronic active antibody-mediated rejection, possibly with other effector T cells, may play a role in graft injury. The role of inflammatory cells in the inflammation and fibrosis and tubular atrophy region has been recently advocated in the progression of injury. Cytotoxic T cells play a prominent role in T-cell-mediated rejection; however, the possible role of cytotoxic T cells in circulation and the intragraft compartment in chronic active antibody-mediated rejection, a common immunological cause of long-term graft failure, has not been well-studied. Materials and methods We measured the frequency of circulating cytotoxic T cells with flow cytometry, serum granzyme B level by enzyme-linked immunosorbent assay and intragraft granzyme B+ cell, and mRNA by immunohistochemistry and real-time polymerase chain reaction in biopsy tissue from living donor renal allograft recipients with stable graft function and chronic active antibody-mediated rejection. Results The frequency of CD3+ and CD3+CD8+ T cells was similar in both stable graft function patients and chronic active antibody-mediated rejection patients. The frequency of CD3+CD8+granzyme B+ cytotoxic T cells was significantly lower in peripheral blood. Serum granzyme B level and intragraft number of granzyme B+ cells (counts/mm²) were also significantly higher in the chronic active antibody-mediated rejection group compared with that of patients with stable graft function. The intragraft granzyme B+ T cell count was positively correlated with serum creatinine and 24-hour urine proteinuria but negatively correlated with estimated glomerular filtration rate. Conclusions Granzyme B mediates covert graft injury in patients with chronic active antibody-mediated rejection in addition to antibody-mediated injury."xsd:string
http://purl.uniprot.org/citations/33349207	http://purl.org/dc/terms/identifier	"doi:10.6002/ect.2020.0225"xsd:string
http://purl.uniprot.org/citations/33349207	http://purl.uniprot.org/core/author	"Agarwal V."xsd:string
http://purl.uniprot.org/citations/33349207	http://purl.uniprot.org/core/author	"Jain M."xsd:string
http://purl.uniprot.org/citations/33349207	http://purl.uniprot.org/core/author	"Prasad N."xsd:string
http://purl.uniprot.org/citations/33349207	http://purl.uniprot.org/core/author	"Yadav B."xsd:string
http://purl.uniprot.org/citations/33349207	http://purl.uniprot.org/core/author	"Agarwal V.'"xsd:string
http://purl.uniprot.org/citations/33349207	http://purl.uniprot.org/core/date	"2020"xsd:gYear
http://purl.uniprot.org/citations/33349207	http://purl.uniprot.org/core/name	"Exp Clin Transplant"xsd:string
http://purl.uniprot.org/citations/33349207	http://purl.uniprot.org/core/pages	"778-784"xsd:string
http://purl.uniprot.org/citations/33349207	http://purl.uniprot.org/core/title	"Hidden Granzyme B-Mediated Injury in Chronic Active Antibody-Mediated Rejection."xsd:string
http://purl.uniprot.org/citations/33349207	http://purl.uniprot.org/core/volume	"18"xsd:string
http://purl.uniprot.org/citations/33349207	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/33349207
http://purl.uniprot.org/citations/33349207	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/33349207
http://purl.uniprot.org/uniprot/#_P10144-mappedCitation-33349207	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/33349207
http://purl.uniprot.org/uniprot/#_J3KQ52-mappedCitation-33349207	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/33349207
http://purl.uniprot.org/uniprot/#_Q67BC3-mappedCitation-33349207	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/33349207
http://purl.uniprot.org/uniprot/#_Q6XGZ2-mappedCitation-33349207	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/33349207
http://purl.uniprot.org/uniprot/#_Q6XGZ3-mappedCitation-33349207	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/33349207
http://purl.uniprot.org/uniprot/#_Q6XGZ4-mappedCitation-33349207	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/33349207
http://purl.uniprot.org/uniprot/P10144	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/33349207
http://purl.uniprot.org/uniprot/J3KQ52	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/33349207
http://purl.uniprot.org/uniprot/Q6XGZ2	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/33349207
http://purl.uniprot.org/uniprot/Q6XGZ4	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/33349207