| http://purl.uniprot.org/citations/33370779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33370779 | http://www.w3.org/2000/01/rdf-schema#comment | "Developmental-regulatory networks often include large gene families encoding mechanistically-related proteins like G-protein-coupled receptors, zinc finger transcription factors and solute carrier (SLC) transporters. In principle, a common mechanism may confer expression of multiple members integral to a developmental process, or diverse mechanisms may be deployed. Using genetic complementation and enhancer-mutant systems, we analyzed the 456 member SLC family that establishes the small molecule constitution of cells. This analysis identified SLC gene cohorts regulated by GATA1 and/or GATA2 during erythroid differentiation. As >50 SLC genes shared GATA factor regulation, a common mechanism established multiple members of this family. These genes included Slc29a1 encoding an equilibrative nucleoside transporter (Slc29a1/ENT1) that utilizes adenosine as a preferred substrate. Slc29a1 promoted erythroblast survival and differentiation ex vivo. Targeted ablation of murine Slc29a1 in erythroblasts attenuated erythropoiesis and erythrocyte regeneration in response to acute anemia. Our results reveal a GATA factor-regulated SLC ensemble, with a nucleoside transporter component that promotes erythropoiesis and prevents anemia, and establish a mechanistic link between GATA factor and adenosine mechanisms. We propose that integration of the GATA factor-adenosine circuit with other components of the GATA factor-regulated SLC ensemble establishes the small molecule repertoire required for progenitor cells to efficiently generate erythrocytes."xsd:string |
| http://purl.uniprot.org/citations/33370779 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1009286"xsd:string |
| http://purl.uniprot.org/citations/33370779 | http://purl.uniprot.org/core/author | "Cai X."xsd:string |
| http://purl.uniprot.org/citations/33370779 | http://purl.uniprot.org/core/author | "Liao R."xsd:string |
| http://purl.uniprot.org/citations/33370779 | http://purl.uniprot.org/core/author | "Xia Y."xsd:string |
| http://purl.uniprot.org/citations/33370779 | http://purl.uniprot.org/core/author | "Keles S."xsd:string |
| http://purl.uniprot.org/citations/33370779 | http://purl.uniprot.org/core/author | "Mao B."xsd:string |
| http://purl.uniprot.org/citations/33370779 | http://purl.uniprot.org/core/author | "Bresnick E.H."xsd:string |
| http://purl.uniprot.org/citations/33370779 | http://purl.uniprot.org/core/author | "Mehta C."xsd:string |
| http://purl.uniprot.org/citations/33370779 | http://purl.uniprot.org/core/author | "Zwifelhofer N.M."xsd:string |
| http://purl.uniprot.org/citations/33370779 | http://purl.uniprot.org/core/author | "Conn D.J."xsd:string |
| http://purl.uniprot.org/citations/33370779 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33370779 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/33370779 | http://purl.uniprot.org/core/pages | "e1009286"xsd:string |
| http://purl.uniprot.org/citations/33370779 | http://purl.uniprot.org/core/title | "GATA factor-regulated solute carrier ensemble reveals a nucleoside transporter-dependent differentiation mechanism."xsd:string |
| http://purl.uniprot.org/citations/33370779 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/33370779 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/33370779 |
| http://purl.uniprot.org/citations/33370779 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/33370779 |
| http://purl.uniprot.org/uniprot/#_E9PZV0-mappedCitation-33370779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33370779 |
| http://purl.uniprot.org/uniprot/#_E9Q0Q5-mappedCitation-33370779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33370779 |
| http://purl.uniprot.org/uniprot/#_E9Q7R8-mappedCitation-33370779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33370779 |
| http://purl.uniprot.org/uniprot/#_A8VP81-mappedCitation-33370779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33370779 |
| http://purl.uniprot.org/uniprot/#_E9Q221-mappedCitation-33370779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33370779 |
| http://purl.uniprot.org/uniprot/#_E9PWY7-mappedCitation-33370779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/33370779 |