| http://purl.uniprot.org/citations/33374830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33374830 | http://www.w3.org/2000/01/rdf-schema#comment | "GABARAP (γ-aminobutyric acid type A receptor-associated protein) and its paralogues GABARAPL1 and GABARAPL2 comprise a subfamily of autophagy-related Atg8 proteins. They are studied extensively regarding their roles during autophagy. Originally, however, especially GABARAPL2 was discovered to be involved in intra-Golgi transport and homotypic fusion of post-mitotic Golgi fragments. Recently, a broader function of mammalian Atg8s on membrane trafficking through interaction with various soluble N-ethylmaleimide-sensitive factor-attachment protein receptors SNAREs was suggested. By immunostaining and microscopic analysis of the Golgi network, we demonstrate the importance of the presence of individual GABARAP-type proteins on Golgi morphology. Furthermore, triple knockout (TKO) cells lacking the whole GABARAP subfamily showed impaired Golgi-dependent vesicular trafficking as assessed by imaging of fluorescently labelled ceramide. With the Golgi apparatus being central within the secretory pathway, we sought to investigate the role of the GABARAP-type proteins for cell surface protein trafficking. By analysing the surfaceome compositionofTKOs, we identified a subset of cell surface proteins with altered plasma membrane localisation. Taken together, we provide novel insights into an underrated aspect of autophagy-independent functions of the GABARAP subfamily and recommend considering the potential impact of GABARAP subfamily proteins on a plethora of processes during experimental analysis of GABARAP-deficient cells not only in the autophagic context."xsd:string |
| http://purl.uniprot.org/citations/33374830 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms22010085"xsd:string |
| http://purl.uniprot.org/citations/33374830 | http://purl.uniprot.org/core/author | "Willbold D."xsd:string |
| http://purl.uniprot.org/citations/33374830 | http://purl.uniprot.org/core/author | "Hoffmann S."xsd:string |
| http://purl.uniprot.org/citations/33374830 | http://purl.uniprot.org/core/author | "Poschmann G."xsd:string |
| http://purl.uniprot.org/citations/33374830 | http://purl.uniprot.org/core/author | "Stuhler K."xsd:string |
| http://purl.uniprot.org/citations/33374830 | http://purl.uniprot.org/core/author | "Dobner J."xsd:string |
| http://purl.uniprot.org/citations/33374830 | http://purl.uniprot.org/core/author | "Simons I.M."xsd:string |
| http://purl.uniprot.org/citations/33374830 | http://purl.uniprot.org/core/author | "Uffing A."xsd:string |
| http://purl.uniprot.org/citations/33374830 | http://purl.uniprot.org/core/author | "Sanwald J.L."xsd:string |
| http://purl.uniprot.org/citations/33374830 | http://purl.uniprot.org/core/date | "2020"xsd:gYear |
| http://purl.uniprot.org/citations/33374830 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/33374830 | http://purl.uniprot.org/core/pages | "E85"xsd:string |
| http://purl.uniprot.org/citations/33374830 | http://purl.uniprot.org/core/title | "Lack of GABARAP-Type Proteins Is Accompanied by Altered Golgi Morphology and Surfaceome Composition."xsd:string |
| http://purl.uniprot.org/citations/33374830 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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