| http://purl.uniprot.org/citations/33390793 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/33390793 | http://www.w3.org/2000/01/rdf-schema#comment | "Deubiquitylating enzyme ubiquitin-specific protease 1 (USP1) has been reported to be aberrantly overexpressed in cancers, and it plays a critical role in regulating various cellular processes, such as cell proliferation, apoptosis, and cell differentiation. However, the role of USP1 in B-cell acute lymphoblastic leukemia (B-ALL) remains largely undefined. USP1 expression in 30 newly diagnosed B-ALL patients was detected by real-time PCR and western blot. We found that USP1 was generally upregulated in the bone marrow cells derived from B-ALL patients. Knockdown of USP1 by siRNA decreased B-ALL cell growth and induced apoptosis. Similarly, pharmacological inhibition of USP1 by SJB3-019A significantly repressed cell proliferation and triggered B-ALL cell apoptosis. Finally, we found that inhibition of USP1 downregulated the expression of ID1 and p-AKT, and upregulated ID1 expression could reverse the suppressive effects of USP1 inhibitor in B-ALL cells. Taken together, these results demonstrate that USP1 promote B-ALL progression at least partially via the ID1/AKT signaling pathway, and USP1 inhibitors might be promising therapeutic application for B-ALL."xsd:string |
| http://purl.uniprot.org/citations/33390793 | http://purl.org/dc/terms/identifier | "doi:10.7150/ijms.47597"xsd:string |
| http://purl.uniprot.org/citations/33390793 | http://purl.uniprot.org/core/author | "Lu T."xsd:string |
| http://purl.uniprot.org/citations/33390793 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/33390793 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/33390793 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/33390793 | http://purl.uniprot.org/core/author | "Xiong J."xsd:string |
| http://purl.uniprot.org/citations/33390793 | http://purl.uniprot.org/core/author | "Kuang X."xsd:string |
| http://purl.uniprot.org/citations/33390793 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/33390793 | http://purl.uniprot.org/core/name | "Int J Med Sci"xsd:string |
| http://purl.uniprot.org/citations/33390793 | http://purl.uniprot.org/core/pages | "245-255"xsd:string |
| http://purl.uniprot.org/citations/33390793 | http://purl.uniprot.org/core/title | "Inhibition of USP1 induces apoptosis via ID1/AKT pathway in B-cell acute lymphoblastic leukemia cells."xsd:string |
| http://purl.uniprot.org/citations/33390793 | http://purl.uniprot.org/core/volume | "18"xsd:string |
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